Journal article

Publication year: 2003

Pages: 435-440

Journal: American Journal of Orthodontics and Dentofacial Orthopedics

Volume number: 123

Issue number: 4

ISSN: 0889-5406

DOI Link: https://doi.org/10.1067/mod.2003.88

Publisher: Elsevier

Abstract: 
The aim of this study was to assess the effect of nandrolone (Deca-Durabolin, AKZO Nobel, Cambridge, United Kingdom) on mandibular growth in juvenile and adult rats with radiographic cephalometry and immunoradiology. Juvenile (n = 16) and adult (n = 16) inbred female Wistar-Kyoto rats were compared. Each group was divided into 2 subgroups with 8 experimental (E) and 8 control (C) animals in each subgroup. Lateral headfilms taken before and after the 70-day study period were analyzed. Body weight and blood serum IGF-I levels were monitored weekly. The results showed marked mandibular growth changes in both the juvenile and the adult E rats. Body weight increase was larger in the E than in the C animals. The IGF-I blood serum levels were similar in the juvenile E and C rats but higher in the adult E animals than in the adult C animals. It was found that the anabolic steroid (Deca-Durabolin) had a significant effect on mandibular growth in both juvenile and adult rats.

Harvard Citation style: Gebhardt, A. and Pancherz, H. (2003) The effect of anabolic steroids on mandibular growth, American Journal of Orthodontics and Dentofacial Orthopedics, 123(4), pp. 435-440. https://doi.org/10.1067/mod.2003.88

APA Citation style: Gebhardt, A., & Pancherz, H. (2003). The effect of anabolic steroids on mandibular growth. American Journal of Orthodontics and Dentofacial Orthopedics. 123(4), 435-440. https://doi.org/10.1067/mod.2003.88