Conference paper

Publication year: 2003

Pages: 2095-2099

Journal: Life Sciences

Volume number: 72

Issue number: 18-19

ISSN: 0024-3205

DOI Link: https://doi.org/10.1016/S0024-3205(03)00067-5

Conference: 1st International Symposium on Non-neuronal Acetylcholine

Publisher: Elsevier

Abstract: 
We investigated the occurrence and distribution of the ligand-binding alpha-subunits of nicotinic acetylcholine receptors in the rat arterial system in situ by means of RT-PCR and immunohistochemistry. Except the alpha9-subunit, all other mammalian non-muscular a-subunits were expressed in the arterial wall - either in endothelial or in smooth muscle cells - suggesting it as a direct target of nicotine and endogenous acetylcholine. The distribution pattern of a-subunits found in smooth muscle cells varied considerably among the individual elastic, muscular and intraparenchymal arteries investigated, suggesting that non-neuronal cholinergic signalling via nicotinic receptors in the vascular wall includes components that are highly specific for individual arteries. (C) 2003 Elsevier Science Inc. All rights reserved.

Harvard Citation style: Brüggmann, D., Lips, K., Pfeil, U., Haberberger, R. and Kummer, W. (2003) Rat arteries contain multiple nicotinic acetylcholine receptor α-subunits, Life Sciences, 72(18-19), pp. 2095-2099. https://doi.org/10.1016/S0024-3205(03)00067-5

APA Citation style: Brüggmann, D., Lips, K., Pfeil, U., Haberberger, R., & Kummer, W. (2003). Rat arteries contain multiple nicotinic acetylcholine receptor α-subunits. Life Sciences. 72(18-19), 2095-2099. https://doi.org/10.1016/S0024-3205(03)00067-5