Journal article

Publication year: 2002

Pages: 6522-6529

Journal: The Journal of Immunology

Volume number: 169

Issue number: 11

ISSN: 0022-1767

DOI Link: https://doi.org/10.4049/jimmunol.169.11.6522

Publisher: American Association of Immunologists

Abstract: 
Type I IFNs (IFN-alpha/beta) modulate innate immune responses. Here we show activation of transcription factor IFN regulatory factor 3, the synthesis of large amounts of IFN-beta mRNA, and type I IFN signal transduction in macrophages infected with Listeria monocytogenes. Expression of the bacterial virulence protein listeriolysin O was necessary, but not sufficient, for efficient IFN-beta production. Signaling through a pathway involving the type I IFN receptor and Stat1 sensitized macrophages to L. monocytogenes-induced cell death in a manner not requiring inducible NO synthase (nitric oxide synthase 2) or protein kinase R, potential effectors of type I IFN action during microbial infections. The data stress the importance of type I IFN for the course of infections with intracellular bacteria and suggest that factors other than listeriolysin O contribute to macrophage death during Listeria infection.

Harvard Citation style: Stockinger, S., Materna, T., Stoiber, D., Bayr, L., Steinborn, R., Kolbe, T., et al. (2002) Production of type IIFN sensitizes macrophages to cell death induced by Listeria monocytogenes, The Journal of Immunology, 169(11), pp. 6522-6529. https://doi.org/10.4049/jimmunol.169.11.6522

APA Citation style: Stockinger, S., Materna, T., Stoiber, D., Bayr, L., Steinborn, R., Kolbe, T., Unger, H., Chakraborty, T., Levy, D., Müller, M., & Decker, T. (2002). Production of type IIFN sensitizes macrophages to cell death induced by Listeria monocytogenes. The Journal of Immunology. 169(11), 6522-6529. https://doi.org/10.4049/jimmunol.169.11.6522