Journal article

Publication year: 2002

Pages: 183-185

Journal: Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis

Volume number: 106

Issue number: 4-5

ISSN: 0049-3848

DOI Link: https://doi.org/10.1016/S0049-3848(02)00181-0

Publisher: Elsevier

Abstract: 
Protein Z enhances the inhibition of factor Xa by protein Z-dependent protease inhibitor (ZPI). Thus, diminution of protein Z should induce prothrombotic tendency due to lowered collactor activity for ZPI. In Factor V Leiden mice, prothrombotic tendency of severe diminution or lack of protein Z was demonstrated. We here present first studies in humans, indicating that diminution of protein Z in factor V Leiden patients aggravates thromboembolic risk. (C) 2002 Elsevier Science Ltd. All rights reserved.

Harvard Citation style: Kemkes-Matthes, B., Nees, M., Kühnel, G., Matzdorff, A. and Matthes, K. (2002) Protein Z influences the prothrombotic phenotype in factor v Leiden patients, Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 106(4-5), Article PII S0049-3848(02)00181-0. pp. 183-185. https://doi.org/10.1016/S0049-3848(02)00181-0

APA Citation style: Kemkes-Matthes, B., Nees, M., Kühnel, G., Matzdorff, A., & Matthes, K. (2002). Protein Z influences the prothrombotic phenotype in factor v Leiden patients. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis. 106(4-5), Article PII S0049-3848(02)00181-0, 183-185. https://doi.org/10.1016/S0049-3848(02)00181-0