Journal article

Publication year: 2002

Pages: 148-154

Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology

Volume number: 102

Issue number: 2

ISSN: 0301-2115

DOI Link: https://doi.org/10.1016/S0301-2115(01)00607-8

Publisher: Elsevier

Abstract: 
Objective: Our Purpose was to investigate interactions between human chorionic gonadotropin (hCG) and angiotensin II (ANG II) in resistance arteries. Study design: Isolated pre-arteriolar vessels of female Sprague-Dawley rats were prepared from the mesenteric arcade and the mesometrium. Dose-response curves were recorded by means of an video-electronic arteriograph system. Results: (1) hCG dilated mesenteric (MA: EC50: 21 +/- 6.9 mU/ml) and uterine (UA; EC50: 256 +/- 44.3 mU/ml)) resistance arteries pre-constricted with ANG II. In the presence of glybenclamide (1 mumol/l), the response of MA was reduced by >50%. (2) After application of hCG for I h, vasoconstriction by ANG 11 was significantly attenuated in MA. This effect was dose-dependent and was not observed in UA. Efficacy of ANG 11 could be restored, when hCG was followed by glybenclamide. Conclusions: hCG may contribute to the reduction in arterial tone seen early in human pregnancy. Its vascular effects are in part mediated by the activation of adenosine 5'-triphosphate-sensitive potassium channels, suggesting a protein kinase A dependent signaling pathway. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

Harvard Citation style: Hermsteiner, M., Zoltan, D. and Künzel, W. (2002) Human chorionic gonadotropin attenuates the vascular response to angiotensin II, European journal of obstetrics & gynecology and reproductive biology, 102(2), Article PII S0301-2115(01)00607-8. pp. 148-154. https://doi.org/10.1016/S0301-2115(01)00607-8

APA Citation style: Hermsteiner, M., Zoltan, D., & Künzel, W. (2002). Human chorionic gonadotropin attenuates the vascular response to angiotensin II. European journal of obstetrics & gynecology and reproductive biology. 102(2), Article PII S0301-2115(01)00607-8, 148-154. https://doi.org/10.1016/S0301-2115(01)00607-8