Journalartikel

Jahr der Veröffentlichung: 2002

Seiten: 1-5

Zeitschrift: Neuroscience

Bandnummer: 115

Heftnummer: 1

ISSN: 0306-4522

eISSN: 1873-7544

DOI Link: https://doi.org/10.1016/S0306-4522(02)00274-9

Verlag: Elsevier

Abstract: 
Previous binding studies have suggested the presence of a so far unknown nicotinic acetylcholine receptor subunit in dorsal root ganglia (Pugh et al., 1995). Here, we investigated whether the most recently identified subunit, alpha10, and its potential interaction partner, alpha9 (Elgoyhen et al., 2001), are expressed in these ganglia. All neurons of rat dorsal root ganglia, but no glial cells, expressed both alpha9 and alpha10 mRNA in in situ hybridization, and exhibited alpha10 immunoreactivity using a newly raised antibody. These findings were confirmed by RT-PCR and western blotting. The data show that dorsal root ganglion neurons coexpress alpha9 and alpha10 nicotinic receptor subunits, thereby providing the first example of neuronal expression of this receptor subunit pair. (C) 2002 IBRO. Published by Elsevier Science Ltd. All rights reserved.

Harvard-Zitierstil: Lips, K., Pfeil, U. and Kummer, W. (2002) Coexpression of α9 and α10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons, Neuroscience, 115(1), Article PII S0306-4522(02)00274-9. pp. 1-5. https://doi.org/10.1016/S0306-4522(02)00274-9

APA-Zitierstil: Lips, K., Pfeil, U., & Kummer, W. (2002). Coexpression of α9 and α10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons. Neuroscience. 115(1), Article PII S0306-4522(02)00274-9, 1-5. https://doi.org/10.1016/S0306-4522(02)00274-9