Journal article

Publication year: 2001

Pages: 842-847

Journal: Acta Anaesthesiologica Scandinavica

Volume number: 45

Issue number: 7

ISSN: 0001-5172

DOI Link: https://doi.org/10.1034/j.1399-6576.2001.045007842.x

Publisher: Wiley

Abstract: 

Background: In a pilot study, the haemodynamic and gas exchange effects of acute hypercapoia during one-lung ventilation in thoracotomy patients were investigated. The effects of normocapnic one-lung ventilation (OLV-N) on haemodynamics and pulmonary gas exchange were compared with those of hypercapnic one-lung ventilation (OLV-H) in 14 patients undergoing pulmonary lobectomy.

Methods: Hypercapnia was induced by decreasing tidal volume until PaCO2 increased to 8-9 kPa. During OLV, minute ventilation was reduced from 8.8 +/-1.7 to 4.2 +/-0.71 min(-1).

Results: Cardiac index (from 3.3 +/-0.6 to 3.9 +/-0.6 l min(-1), P <0.01) and pulmonary vascular resistance index (from 245 +/- 96 to 347 +/- 125 dyn s cm(-5) m(-2), P <0.05) increased during OLV-H, whereas systemic vascular resistance index decreased from 1952 +/- 403 to 1636 +/- 361 dyn s cm(-5) m(-2) (P <0.01). Pulmonary oxygenation remained unchanged.

Conclusions: All patients had an uneventful course during OLV-H. The determinants of pulmonary oxygenation during hypercapnic one-lung ventilation remain to be further elucidated.

Harvard Citation style: Sticher, J., Müller, M., Scholz, S., Schindler, E. and Hempelmann, G. (2001) Controlled hypercapnia during one-lung ventilation in patients undergoing pulmonary resection, Acta Anaesthesiologica Scandinavica, 45(7), pp. 842-847. https://doi.org/10.1034/j.1399-6576.2001.045007842.x

APA Citation style: Sticher, J., Müller, M., Scholz, S., Schindler, E., & Hempelmann, G. (2001). Controlled hypercapnia during one-lung ventilation in patients undergoing pulmonary resection. Acta Anaesthesiologica Scandinavica. 45(7), 842-847. https://doi.org/10.1034/j.1399-6576.2001.045007842.x