Journal article
Authors list: Kemkes-Matthes, B
Publication year: 2001
Pages: 433-437
Journal: Zentralblatt für Chirurgie
Volume number: 126
Issue number: 6
ISSN: 0044-409X
DOI Link: https://doi.org/10.1055/s-2001-14762
Publisher: Georg Thieme Verlag
Abstract:
Using laboratory testing, coagulation alterations can be detected in about 50 % of familial thrombophilia. Most common hereditary coagulation defects leading to enhanced thrombosis risk are aPC resistance/Factor V Leiden mutation, protein C- and S-deficiency, prothrombin 20210A polymorphism and antithrombin deficiency. Moreover, elevated plasma levels of homocysteine also are associated with enhanced thrombosis risk. Severity of thromboembolic risk depends upon type of coagulation defect, hetero- or homocygosity and occurrence of additional acquired risk factors like immobilisation. Therapy of thromboembolic diseases must always be planned considering both clinical circumstances and laboratory findings.
Citation Styles
Harvard Citation style: Kemkes-Matthes, B. (2001) Diagnostic measures for evaluation of thrombophilia, Zentralblatt für Chirurgie, 126(6), pp. 433-437. https://doi.org/10.1055/s-2001-14762
APA Citation style: Kemkes-Matthes, B. (2001). Diagnostic measures for evaluation of thrombophilia. Zentralblatt für Chirurgie. 126(6), 433-437. https://doi.org/10.1055/s-2001-14762
Keywords
Factor V Leiden; protein C; protein S; prothrombin polymorphism; thromboembolic risk; VENOUS THROMBOSIS
