Journalartikel

Jahr der Veröffentlichung: 2001

Seiten: 873-879

Zeitschrift: European Journal of Clinical Pharmacology

Bandnummer: 56

Heftnummer: 12

ISSN: 0031-6970

eISSN: 1432-1041

DOI Link: https://doi.org/10.1007/s002280000254

Verlag: Springer

Abstract: 

Objective: 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors have been suggested as agents to reduce the biliary cholesterol saturation index (CSI) in duodenal bile and therefore might be supportive in primary or secondary prevention of gallstones. However, the efficiency of the therapy seems to depend on both the HMG-CoA reductase inhibitor used and the study population selected.

Methods: We therefore investigated the effect of a high-dose application of fluvastatin on biliary lipid composition in 21 subjects exhibiting mild hypercholesterolaemia and a history of current gallstones or cholecystectomy due to gallstone disease. Subjects were treated either with 40 mg fluvastatin twice per day over a 3-month period (n = 14) or with placebo (n = 7). Bile samples were aspirated during endoscopy after intravenous ceruletid stimulation before and after therapy.

Results: Both groups were comparable in CSI (mean +/- SD) at baseline (1.78 +/- 0.2 placebo vs. 1.97 +/- 0.4 verum). CSI significantly decreased in the verum group to 1.45 +/- 0.4 (P = 0.003) mainly due to increased phospholipid levels, whereas no difference was observed in the placebo group (1.85 +/- 0.7, n.s.). In addition, the verum group exhibited a significant reduction of hydrophobic deoxycholic acid, which has been reported to induce cholesterol crystal precipitation, and an increase of hydrophilic cholic acid.

Conclusion: Fluvastatin might decrease the risk of cholesterol gallstone formation in patients with elevated biliary CSI during long-term treatment by reduction of biliary cholesterol saturation and percentage change in deoxycholic acid content.

Harvard-Zitierstil: Porsch-Özçürümez, M., Hardt, P., Schnell-Kretschmer, H., von Bergmann, K., Darui, C., Nonhoff, J., et al. (2001) Effects of fluvastatin on biliary lipids in subjects with an elevated cholesterol saturation index, European Journal of Clinical Pharmacology, 56(12), pp. 873-879. https://doi.org/10.1007/s002280000254

APA-Zitierstil: Porsch-Özçürümez, M., Hardt, P., Schnell-Kretschmer, H., von Bergmann, K., Darui, C., Nonhoff, J., Abletshauser, C., & Klör, H. (2001). Effects of fluvastatin on biliary lipids in subjects with an elevated cholesterol saturation index. European Journal of Clinical Pharmacology. 56(12), 873-879. https://doi.org/10.1007/s002280000254