Conference paper

Editor list: Nieuwenhuizen, W; Mosesson, MW; DeMaat, MPM

Publication year: 2001

Pages: 617-620

Journal: Annals of the New York Academy of Sciences

Volume number: 936

ISSN: 0077-8923

ISBN: 1-57331-314-9

Conference: 16th International Fibrinogen Workshop

Publisher: Wiley

Title of series: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Abstract: 
In a prospective investigation of perioperative cardiac edema formation requiring a delayed sternal closure, we identified thrombin increase combined with a simultaneous decrease of factor XIII as a probable cause. After experimental studies additionally revealed that factor XIII could protect endothelial barrier function, we did another prospective randomized trial in which factor XIII or placebo was preoperatively substituted. The substitution finally showed distinct effects minimizing the incidence of myocardial swelling. Therefore, the clinical application of factor XIII may have a valuable therapeutic benefit In cases of leakage syndrome during extracorporeal circulation in congenital heart surgery.

Harvard Citation style: Wozniak, G., Noll, T., Akintürk, H., Thul, J. and Müller, M. (2001) Factor XIII prevents development of myocardial edema in children undergoing surgery for congenital heart disease, Annals of the New York Academy of Sciences, 936, pp. 617-620

APA Citation style: Wozniak, G., Noll, T., Akintürk, H., Thul, J., & Müller, M. (2001). Factor XIII prevents development of myocardial edema in children undergoing surgery for congenital heart disease. Annals of the New York Academy of Sciences. 936, 617-620.