Journal article

Publication year: 2000

Pages: 31-36

Journal: Acta Neurologica Scandinavica

Volume number: 102

Issue number: 1

ISSN: 0001-6314

Open access status: Gold

DOI Link: https://doi.org/10.1034/j.1600-0404.2000.102001031.x

Publisher: Wiley

Abstract: 
Objectives - In this study the frequency of inherited thrombophilic risk factors in a population of German CVT patients and their influence on clinical outcome were evaluated. Material and methods - Twenty-five patients (age 37.1 +/- 16.3 years) with CVT were screened for inherited coagulation disorders. All participants received a full clinical follow-up (mean follow-up period 4.8 +/- 6.4 years). Results - Inherited thrombophilic risk factors were identified in 9 (36%) of the 25 patients studied. Four were found positive for the heterozygous factor V Leiden mutation, 2 were heterozygous carriers of the prothrombin-G20210A-polymorphism. APC resistance proved to be a reliable screening method for factor V Leiden mutation, whereas genetic evaluation for protein S and C deficiencies failed to demonstrate any mutations despite the identification of 1 patient with a protein C and protein S deficiency each. One patient suffered from a familial plasminogen deficiency. These 9 patients had a less favorable outcome (P < 0.05). Conclusion - Our results demonstrate that screening for inherited thrombophilia should be an integral part in the diagnostic work up of CVT patients. Patients with inherited coagulopathies tended to have a less favorable outcome, corroborating recommendations for a longer period of oral anticoagulation.

Harvard Citation style: Stolz, E., Kemkes-Matthes, B., Pötzsch, B., Hahn, M., Kraus, J., Wirbartz, A., et al. (2000) Screening for thrombophilic risk factors among 25 German patients with cerebral venous thrombosis, Acta Neurologica Scandinavica, 102(1), pp. 31-36. https://doi.org/10.1034/j.1600-0404.2000.102001031.x

APA Citation style: Stolz, E., Kemkes-Matthes, B., Pötzsch, B., Hahn, M., Kraus, J., Wirbartz, A., & Kaps, M. (2000). Screening for thrombophilic risk factors among 25 German patients with cerebral venous thrombosis. Acta Neurologica Scandinavica. 102(1), 31-36. https://doi.org/10.1034/j.1600-0404.2000.102001031.x