Journal article

Publication year: 1999

Pages: 59-66

Journal: General pharmacology

Volume number: 33

Issue number: 1

ISSN: 0306-3623

DOI Link: https://doi.org/10.1016/S0306-3623(98)00270-5

Publisher: Pergamon

Abstract: 
In vitro experiments were performed on a standardized preparation of the autonomously contractile bulbus cordis branchialis of the branchial heart of Sepia officinalis to investigate its cholinergic neuroregulation. Apart from acetylcholine, nicotine and carbachol (nicotinic agonists), the muscarinic agonists muscarine, arecoline, pilocarpine, and oxotremorine also exerted concentration-dependent negative inotropic effects on the preparations. As both the muscarinic antagonist quinuclidinylbenzilate and the nicotinic antagonist alpha-bungarotoxin blocked the ACh action there might be a special, possibly mixed muscarinic/nicotinic ACh-receptor system in the myocytes of the bulbus cordis branchialis, which is different from the cholinergic receptor in the central part of the branchial heart. (C) 1999 Elsevier Science Inc. All rights reserved.

Harvard Citation style: Gebauer, M., Versen, B. and Schipp, R. (1999) Inhibitory cholinergic effects on the autonomously contractile bulbus cordis branchialis of the cephalopod Sepia officinalis L., General pharmacology, 33(1), pp. 59-66. https://doi.org/10.1016/S0306-3623(98)00270-5

APA Citation style: Gebauer, M., Versen, B., & Schipp, R. (1999). Inhibitory cholinergic effects on the autonomously contractile bulbus cordis branchialis of the cephalopod Sepia officinalis L.. General pharmacology. 33(1), 59-66. https://doi.org/10.1016/S0306-3623(98)00270-5