Journal article

Publication year: 1999

Pages: 123-131

Journal: Journal of veterinary medicine. Series A: Physiology, pathology, clinical medicine

Volume number: 46

Issue number: 2

ISSN: 0931-184X

DOI Link: https://doi.org/10.1046/j.1439-0442.1999.00200.x

Publisher: Blackwell Verlag

Abstract: 

The effect of inhibitors of the thromboxane A(2) pathway on spontaneous contractions of intestinal smooth muscle preparations was studied. The thromboxane A? antagonists Bay u3405, SK and F 88046 and KW-3635 concentration-dependently inhibited both the amplitude and the frequency of spontaneous contractions of the longitudinal muscle from the rat proximal colon. A concentration-dependent inhibition of the myogenic contractions was also observed with the thromboxane A(2) synthase inhibitor U-51605, and with the combined cyclooxygenase/lipoxygenase inhibitor nordihydroguaiaretic acid, whereas indomethacin, a pure cyclooxygenase inhibitor, was ineffective. None of these inhibitors affected the contractile response evoked by the cholinergic agonist carbachol, excluding non-specific actions on intestinal motility.

A similar response was observed for the rabbit jejunum, which, in contrast to the rat colon, exhibits more regular, high-frequency spontaneous contractions, which were inhibited by Bay u3405, SK and F 88046 and KW-3635 in a concentration-dependent manner, whereas the response to carbachol remained unaffected. These results suggest a role for thromboxane A(2) in the generation and/or facilitation of spontaneous smooth muscle contractions in the gut.

Harvard Citation style: Schultheiss, G. and Diener, M. (1999) Inhibition of Spontaneous Smooth Muscle Contractions in Rat and Rabbit Intestine by Blockers of the Thromboxane A2 Pathway, Journal of veterinary medicine. Series A: Physiology, pathology, clinical medicine, 46(2), pp. 123-131. https://doi.org/10.1046/j.1439-0442.1999.00200.x

APA Citation style: Schultheiss, G., & Diener, M. (1999). Inhibition of Spontaneous Smooth Muscle Contractions in Rat and Rabbit Intestine by Blockers of the Thromboxane A2 Pathway. Journal of veterinary medicine. Series A: Physiology, pathology, clinical medicine. 46(2), 123-131. https://doi.org/10.1046/j.1439-0442.1999.00200.x