Journal article

Publication year: 1999

Pages: 135-142

Journal: Histochemistry and Cell Biology

Volume number: 111

Issue number: 2

ISSN: 0301-5564

DOI Link: https://doi.org/10.1007/s004180050343

Publisher: Springer

Abstract: 
The secretory vesicles of some cells of the islets of Langerhans of the pancreas contain high amounts of immunoreactive tyrosine phosphatase of the PTP1B/TCPTP subfamily. The cells are located in the peripheral parts of the islets and were identified as glucagon- and pancreatic polypeptide-forming cells. The tyrosine phosphatase is also enriched in some of the somatostatin-producing cells but is not elevated either in insulin-producing B-cells or in the exocrine pancreas. Virtually the same patterns were found in pancretic tissues of rats, guinea pigs, pigs, and mice. High levels of detergent-soluble tyrosine phosphatase were measured in the particular fraction of pancreatic islets with a substrate preferred by PTP1B/TCPTP-type protein tyrosine phosphatases.

Harvard Citation style: Wimmer, M., Tag, C. and Hofer, H. (1999) A non-receptor-type protein phosphotyrosine phosphatase is enriched in secretory vesicles of glucagon - and pancreatic polypeptide - secreting cells of the endocrine pancreas, Histochemistry and Cell Biology, 111(2), pp. 135-142. https://doi.org/10.1007/s004180050343

APA Citation style: Wimmer, M., Tag, C., & Hofer, H. (1999). A non-receptor-type protein phosphotyrosine phosphatase is enriched in secretory vesicles of glucagon - and pancreatic polypeptide - secreting cells of the endocrine pancreas. Histochemistry and Cell Biology. 111(2), 135-142. https://doi.org/10.1007/s004180050343