Conference paper

Editor list: Cutolo, M; Masi, AT; Bijlsma, JWJ; Chikanza, IC; Bradlow, HL; Castagnetta, L

Publication year: 1999

Pages: 325-339

Journal: Annals of the New York Academy of Sciences

Volume number: 876

ISSN: 0077-8923

ISBN: 1-57331-216-9

DOI Link: https://doi.org/10.1111/j.1749-6632.1999.tb07657.x

Conference: 1st International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases

Publisher: Wiley

Title of series: Annals of the New York Academy of Sciences

Abstract: 
The symptomatology characterizing fibromyalgia (FM) comprises three systems: the musculoskeletal system with widespread muscular pain, neuroendocrine disorders, and psychological distress including depression. Though the most prominent symptom of FM is pain in defined points of the musculoskeletal system, the numerous other somatoform and psychological disorders suppose a common primary disturbance which we consider to originate within higher levels of the central nervous system. Recent studies of the entire endocrine profile of FM patients following a simultaneous challenge of the hypophysis with corticotropin-releasing hormone (CRH), thyrotropin-releasing hormone, growth hormone-releasing hormone, and luteinizing hormone-releasing hormone support the hypothesis that an elevated activity of CRH neurons determines not only many symptoms of FM but may also cause the deviations observed in the other hormonal axes, Hypothalamic CRH neurons thus may play a key role not only in "resetting" the various endocrine loops but possibly also nociceptive and psychological mechanisms as well.

Harvard Citation style: Neeck, G. and Riedel, W. (1999) Hormonal pertubations in fibromyalgia syndrome, Annals of the New York Academy of Sciences, 876, pp. 325-339. https://doi.org/10.1111/j.1749-6632.1999.tb07657.x

APA Citation style: Neeck, G., & Riedel, W. (1999). Hormonal pertubations in fibromyalgia syndrome. Annals of the New York Academy of Sciences. 876, 325-339. https://doi.org/10.1111/j.1749-6632.1999.tb07657.x