Journal article

Publication year: 1998

Pages: 107-112

Journal: FEMS Microbiology Letters

Volume number: 163

Issue number: 2

ISSN: 0378-1097

eISSN: 1574-6968

DOI Link: https://doi.org/10.1111/j.1574-6968.1998.tb13033.x

Publisher: Oxford University Press

Abstract: 
Attaching and effacing Escherichia coli (AEEC) are extracellular pathogens that induce the formation of actin-rich structures at their sites of attachment to eukaryotic host cells. We analysed whether small GTP-binding proteins of the Rho- and Ras-subfamilies, which control the cellular actin system, are essential for these bacterial-induced microfilament reorganizations. For this purpose we specifically inactivated them using the Clostridium difficile toxins TcdB-10463 and TcdB-1470. Such treatment led to a dramatic breakdown of the normal actin cytoskeleton, but did not abrogate the bacterial-induced actin rearrangements. Our data therefore indicate that the microfilament reorganizations induced by AEEC are independent of those small GTP-binding proteins that under normal conditions control the dynamics and maintenance of the actin cytoskeleton. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V, All rights reserved.

Harvard Citation style: Ebel, F., von Eichel-Streiber, C., Rohde, M. and Chakraborty, T. (1998) Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli, FEMS Microbiology Letters, 163(2), pp. 107-112. https://doi.org/10.1111/j.1574-6968.1998.tb13033.x

APA Citation style: Ebel, F., von Eichel-Streiber, C., Rohde, M., & Chakraborty, T. (1998). Small GTP-binding proteins of the Rho- and Ras-subfamilies are not involved in the actin rearrangements induced by attaching and effacing Escherichia coli. FEMS Microbiology Letters. 163(2), 107-112. https://doi.org/10.1111/j.1574-6968.1998.tb13033.x