Journalartikel

Jahr der Veröffentlichung: 1997

Seiten: 1696-1703

Zeitschrift: European Journal of Immunology

Bandnummer: 27

Heftnummer: 7

ISSN: 0014-2980

DOI Link: https://doi.org/10.1002/eji.1830270716

Verlag: Wiley

Abstract: 
We have examined the influence of listeriolysin O (LLO), the hemolysin secreted by the pathogenic bacterium Listeria monocytogenes, on major histocompatibility complex class II-dependent T cell activation. Stimulation of T cells by native antigens but not by peptides is inhibited upon pretreatment of antigen-presenting cells (APC) with LLO. Experiments presented here reveal that this inhibition is not due to a lack in processing of antigen by APC but is the result of an irreversible inactivation of T cells that recognize antigen on LLO-treated APC. Incubation of mixtures of two different T cells where only one antigen was presented on LLO-treated APC suggested that T cell inactivation is antigen specific. The inactivation was dominant and could be observed even in the presence of amounts of synthetic peptides that normally lead to T sell responses. This condition is reminiscent of the T cell inhibition observed when antagonistic and stimulatory peptides are added to APC at the same time. Our results thus reveal a novel type of interference by pathogens with antigen presentation and T cell stimulation that could give the pathogen a decisive advantage in dissemination and disease.

Harvard-Zitierstil: Darji, A., Stockinger, B., Wehland, J., Chakraborty, T. and Weiss, S. (1997) Antigen-specific T cell receptor antagonism by antigen-presenting cells treated with the hemolysin of Listeria monocytogenes: A novel type of immune escape, European Journal of Immunology, 27(7), pp. 1696-1703. https://doi.org/10.1002/eji.1830270716

APA-Zitierstil: Darji, A., Stockinger, B., Wehland, J., Chakraborty, T., & Weiss, S. (1997). Antigen-specific T cell receptor antagonism by antigen-presenting cells treated with the hemolysin of Listeria monocytogenes: A novel type of immune escape. European Journal of Immunology. 27(7), 1696-1703. https://doi.org/10.1002/eji.1830270716