Conference paper

Publication year: 1997

Pages: 33-37

Journal: Immunology Letters

Volume number: 57

Issue number: 1-3

ISSN: 0165-2478

DOI Link: https://doi.org/10.1016/S0165-2478(97)00071-0

Conference: 13th European Immunology Meeting

Publisher: Elsevier

Abstract: 
Antigen presenting cells (APC) that are infected with listeriolysin (LLO) secreting Listeria lack the ability to stimulate MHC class II restricted T-cells by conventional antigens. Similarly, T-cell activation by native proteins but not by peptides was inhibited upon pretreatment of APC with purified listeriolysin. The inhibition is due to an irreversible inactivation of T-cells that recognize antigen on infected or LLO treated APC. Inhibition was found to dominate over stimulation by peptides. This condition is reminiscent of T-cell inactivation by antagonistic peptides and represents a novel type of immune escape. (C) 1997 Elsevier Science B.V.

Harvard Citation style: Darji, A., Stockinger, B., Wehland, J., Chakraborty, T. and Weiss, S. (1997) T-cell anergy induced by antigen presenting cells treated with the hemolysin of Listeria monocytogenes, Immunology Letters, 57(1-3), pp. 33-37. https://doi.org/10.1016/S0165-2478(97)00071-0

APA Citation style: Darji, A., Stockinger, B., Wehland, J., Chakraborty, T., & Weiss, S. (1997). T-cell anergy induced by antigen presenting cells treated with the hemolysin of Listeria monocytogenes. Immunology Letters. 57(1-3), 33-37. https://doi.org/10.1016/S0165-2478(97)00071-0