Journal article

Publication year: 1997

Pages: 245-250

Journal: Journal of Endocrinological Investigation

Volume number: 20

Issue number: 5

ISSN: 0391-4097

DOI Link: https://doi.org/10.1007/BF03350295

Publisher: Springer

Abstract: 
3 alpha-androstanediol glucuronide (3 alpha diolG) is a marker of peripheral tissue androgen metabolism. There are no previous data regarding complete paediatric reference ranges for 3 alpha diolG. In order to obtain reference values for 3 alpha diolG we have measured serum levels of 3 alpha diolG in 283 healthy children and adolescents, 146 boys and 137 girls, age 1 month to 20 years and 28 adults. A non-extraction, solid phase radioimmunoassay employing a polyclonal antiserum that is specific for 3 alpha diolG was used to measure serum 3 alpha diolG levels (intra assay variation 5.1-10.1%, inter assay variation 2.7-9.0%). There was a strong sex and age dependence (r = 0.8; p < 0.0001) of 3 alpha diolG levels throughout childhood and adolescence with males showing significantly higher levels of the androgen than females (p < 0.05). 3 alpha diolG serum levels (nmol/l +/- SD) correlated significantly with pubertal stage (p < 0.01). Interestingly, in 35 children with CAH serum 3 alpha diolG levels correlated well with clinical and metabolic status, i.e. 170HP serum levels. In summary, we have established percentile curves for 3 alpha diolG levels in healthy children and adolescents. We hypothesize that on the basis of our reference values the single measurement of serum 3 alpha diolG could serve as a means to determine androgen status in children with disorders of puberty and sexual development. (C) 1997, Editrice Kurtis.

Harvard Citation style: Rittner, H., Lee, P., Blum, W., Doerr, H., Steiss, J., Kreuder, J., et al. (1997) Developmental patterns of serum 3 alpha-androstanediol glucuronide, Journal of Endocrinological Investigation, 20(5), pp. 245-250. https://doi.org/10.1007/BF03350295

APA Citation style: Rittner, H., Lee, P., Blum, W., Doerr, H., Steiss, J., Kreuder, J., Rascher, W., & Kiess, W. (1997). Developmental patterns of serum 3 alpha-androstanediol glucuronide. Journal of Endocrinological Investigation. 20(5), 245-250. https://doi.org/10.1007/BF03350295