Journalartikel

Jahr der Veröffentlichung: 1997

Seiten: 234-239

Zeitschrift: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie

Bandnummer: 32

Heftnummer: 4

ISSN: 0939-2661

DOI Link: https://doi.org/10.1055/s-2007-995043

Verlag: Georg Thieme Verlag

Abstract: 
Objective: The aim of this study was to investigate the incidence of septic complications, the immunological changes by the course of lymphocyte subsets and metabolic parameters on polytraumatised patients when given nutritional support in form of early enteral and total parenteral nutrition. Furthermore, we looked for differences between a standard enteral diet and a diet supplemented with arginine, omega-3-fatty acids, nucleotide, and selenium. Methods: 30 polytraumatised patients with an Acute Physiology and Chronic Health Evaluation II (APACHE II)-Score >10 points, who received nutritional support for a minimum of 7 days, were randomised to a ''supplemented enteral group'' (group 1), an ''enteral standard group'' (group 2), or a ''parenteral group'' (group 3). in the first both groups there were early enteral feeding. The patients of group 3 were fed isonitrogenous and isocaloric to group 2. Leucocytes, lymphocytes, CD3(+)-, CD4(+)-, CD3(+)HLA-DR+-, CD8(+)-, CD19(+)-subsets, natural killer-cells (CD56(+)) and metabolic parameters were measured on days 1, 3, 5, 7. Results: Septic complications occurred in 2 patients in group 1, in 1 patient in group 2 and in 4 patients in group 3. The total number of lymphocytes had an increase on day 7 in group 1 (1420/mu l) and group 2 (1620/mu l) and were higher compared with group 3 (1044/mu l). On day 7 T-cells (CD3(+)) were 1107/mu l in group 1, 1014/mu l in group 2 and 770/mu l in group 3. T-helper-cells (CD4(+)) rose on day 7 higher in the enteral fed groups (group 1 :746/mu l, group 2:719/mu l) than in group 3 (570/mu l). No significant differences between the groups were seen by CD3(+)HLA-DR+-cells. T-suppressor-cells (CD8(+)), B-cells (CD19(+)) and natural killer-cells (CD56). Conclusion: Early enteral nutrition seems to stabilise the immunosuppression of polytraumatised patients in an earlier phase. There is a consolidation of the lymphocyte counts, and of T(CD3(+))- and T-helper-cells (CD4(+)). This could be the immunological correlate for the number of septic complications in the enteral fed groups. Therefore polytraumatised patients should be fed rather early enteral than parenteral when possible. In the initial phase after the trauma the way of nutritional support has more importance on the immune system as nutritional contents. So, in this form of studying, there is no advantage of immunonutrition.

Harvard-Zitierstil: Engel, J., Menges, T., Neuhauser, C., Schaefer, B. and Hempelmann, G. (1997) Effects of different feeding regimes on septic complications and immune parameters in polytraumatised patients., Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie, 32(4), pp. 234-239. https://doi.org/10.1055/s-2007-995043

APA-Zitierstil: Engel, J., Menges, T., Neuhauser, C., Schaefer, B., & Hempelmann, G. (1997). Effects of different feeding regimes on septic complications and immune parameters in polytraumatised patients.. Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie. 32(4), 234-239. https://doi.org/10.1055/s-2007-995043