Journal article

Publication year: 1997

Pages: 421-428

Journal: The Journal of Infectious Diseases

Volume number: 175

Issue number: 2

ISSN: 0022-1899

Open access status: Bronze

DOI Link: https://doi.org/10.1093/infdis/175.2.421

Publisher: Oxford University Press

Abstract: 
Surfactant protein A (SP-A) contributes to host defense by opsonizing microbial organisms for phagocytosis by alveolar macrophages (AM). The role of SP-A as opsonin for phagocytosis of Candida albicans was analyzed. AM in suspension exhibited no phagocytosis of nonopsonized yeast. This was not increased by SP-A, whether provided for preincubation of AM or yeast or present during coincubation. However, the engulfment of serum-opsonized yeast by AM in suspension was inhibited by SP-A. This inhibitory effect was mimicked by complement subcomponent Clq and concanavalin A but not by type IV collagen. SP-A did not interfere with phagocytosis of serum-opsonized yeast by adherent AM, monocytes, neutrophils, or peritoneal macrophages. SP-A lacks function as an opsonin for the phagocytosis of C. albicans by AM but interferes with binding of yeast to AM, inhibiting subsequent ingestion. The role of SP-A as an alveolar space opsonin may thus critically depend on the microbial species involved.

Harvard Citation style: Rosseau, S., Guenther, A., Seeger, W. and Lohmeyer, J. (1997) Phagocytosis of viable Candida albicans by alveolar macrophages: Lack of opsonin function of surfactant protein A, The Journal of Infectious Diseases, 175(2), pp. 421-428. https://doi.org/10.1093/infdis/175.2.421

APA Citation style: Rosseau, S., Guenther, A., Seeger, W., & Lohmeyer, J. (1997). Phagocytosis of viable Candida albicans by alveolar macrophages: Lack of opsonin function of surfactant protein A. The Journal of Infectious Diseases. 175(2), 421-428. https://doi.org/10.1093/infdis/175.2.421