Journalartikel

Jahr der Veröffentlichung: 1996

Seiten: 2356-2358

Zeitschrift: Infection and Immunity

Bandnummer: 64

Heftnummer: 6

ISSN: 0019-9567

Open Access Status: Green

DOI Link: https://doi.org/10.1128/IAI.64.6.2356-2358.1996

Verlag: American Society for Microbiology

Abstract: 
Six different mouse monoclonal antibodies (MAbs) and a specific rabbit polyclonal antibody were raised against listeriolysin, Four of the MAbs also recognized seeligeriolysin, and five cross-reacted with ivanolysin. The hemolytic activity could be neutralized by the polyclonal antibody as well as by five of the MAbs. None of the neutralizing antibodies interfered with the binding of listeriolysin to the cellular membrane. The epitopes recognized by the MAbs were localized by using overlapping synthetic peptides between positions 59 and 279, a region hitherto not implicated in mediating hemolytic activity.

Harvard-Zitierstil: Darji, A., Niebuhr, K., Hense, M., Wehland, J., Chakraborty, T. and Weiss, S. (1996) Neutralizing monoclonal antibodies against listeriolysin: Mapping of epitopes involved in pore formation, Infection and Immunity, 64(6), pp. 2356-2358. https://doi.org/10.1128/IAI.64.6.2356-2358.1996

APA-Zitierstil: Darji, A., Niebuhr, K., Hense, M., Wehland, J., Chakraborty, T., & Weiss, S. (1996). Neutralizing monoclonal antibodies against listeriolysin: Mapping of epitopes involved in pore formation. Infection and Immunity. 64(6), 2356-2358. https://doi.org/10.1128/IAI.64.6.2356-2358.1996