Journal article

Publication year: 1996

Pages: 674-676

Journal: Infection and Immunity

Volume number: 64

Issue number: 2

ISSN: 0019-9567

Open access status: Green

DOI Link: https://doi.org/10.1128/IAI.64.2.674-676.1996

Publisher: American Society for Microbiology

Abstract: 
The impact of Listeria monocytogenes listeriolysin O (LLO) secretion on phosphoinositide metabolism and mediator (platelet-activating factor and prostaglandin I-2) generation was investigated in human umbilical vein endothelial cells. Wild-type L. monocytogenes, purified LLO, and an L. innocua strain engineered to secrete LLO all elicited a strong response, whereas mutant strains defective in LLO production were ineffective. Thus, human umbilical vein endothelial cell stimulation by listeriae is linked to production of LLO.

Harvard Citation style: Sibelius, U., Rose, F., Chakraborty, T., Darji, A., Wehland, J., Weiss, S., et al. (1996) Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells, Infection and Immunity, 64(2), pp. 674-676. https://doi.org/10.1128/IAI.64.2.674-676.1996

APA Citation style: Sibelius, U., Rose, F., Chakraborty, T., Darji, A., Wehland, J., Weiss, S., Seeger, W., & Grimminger, F. (1996). Listeriolysin is a potent inducer of the phosphatidylinositol response and lipid mediator generation in human endothelial cells. Infection and Immunity. 64(2), 674-676. https://doi.org/10.1128/IAI.64.2.674-676.1996