Journal article

Publication year: 1995

Pages: 312-316

Journal: Haemostasis

Volume number: 25

Issue number: 6

ISSN: 0301-0147

Publisher: Karger

Abstract: 
Protein Z is a vitamin K-dependent plasma protein, which promotes the association of thrombin with phospholipid surfaces. Deficiency states of protein Z have recently been shown in patients with a bleeding tendency of an otherwise unknown origin. In the present study severe diminutions of blood plasma protein Z were found in patients with chronic liver diseases. Protein Z levels decreased with increasing severity of liver disease. Strong correlations between protein Z and other plasma proteins of liver origin indicate that protein Z primarily originates from the liver. The cutaneous bleeding tendency in cirrhosis may in part be due to protein Z deficiency.

Harvard Citation style: KEMKESMATTHES, B. and MATTHES, K. (1995) PROTEIN-Z, A NEW HEMOSTATIC FACTOR, IN LIVER-DISEASES, HAEMOSTASIS, 25(6), pp. 312-316

APA Citation style: KEMKESMATTHES, B., & MATTHES, K. (1995). PROTEIN-Z, A NEW HEMOSTATIC FACTOR, IN LIVER-DISEASES. HAEMOSTASIS. 25(6), 312-316.