Journal article

Publication year: 1995

Pages: 21-28

Journal: Histochemistry and Cell Biology

Volume number: 104

Issue number: 1

ISSN: 0301-5564

DOI Link: https://doi.org/10.1007/BF01464782

Publisher: Springer

Abstract: 
Nitric oxide synthase (NOS) has previously been reported in a small population of postganglionic sympathetic neurons in the guinea pig. The present study of paravertebral ganglia and the inferior mesenteric ganglion aimed to classify these neurons according to their content of neuropeptides (calcitonin gene-related peptide, neuropeptide Y, vasoactive intestinal peptide) and the rate-limiting enzyme of catecholamine synthesis, tyrosine hydroxylase, by means of immunohistochemical and histochemical double-labelling techniques. NOS-containing neurons belonged to the non-catecholaminergic population of postganglionic neurons, and partial co-existence was found with neuropeptide Y and vasoactive intestinal peptide immunoreactivities but not with calcitonin gene-related peptide. However, most of the NOS-containing neurons contained none of the neuropeptides, thus representing a hitherto unrecognized population of postganglionic neurons. The findings show that NOS is localized to small but neurochemically highly specific populations of postganglionic neurons, which most likely reflects an association with target- and function-specific pathways.

Harvard Citation style: Höhler, B., Olry, R., Mayer, B. and Kummer, W. (1995) Nitric oxide synthase in guinea pig sympathetic ganglia: Correlation with tyrosine hydroxylase and neuropeptides, Histochemistry and Cell Biology, 104(1), pp. 21-28. https://doi.org/10.1007/BF01464782

APA Citation style: Höhler, B., Olry, R., Mayer, B., & Kummer, W. (1995). Nitric oxide synthase in guinea pig sympathetic ganglia: Correlation with tyrosine hydroxylase and neuropeptides. Histochemistry and Cell Biology. 104(1), 21-28. https://doi.org/10.1007/BF01464782