Journal article
Authors list: Melk, A; Mueller-Eckhardt, G; Polten, B; Lattermann, A; Heine, O; Hoffmann, O
Publication year: 1995
Pages: 228-233
Journal: American Journal of Reproductive Immunology
Volume number: 33
Issue number: 3
ISSN: 8755-8920
DOI Link: https://doi.org/10.1111/j.1600-0897.1995.tb00889.x
Publisher: Wiley
PROBLEM: The role of ACA in unexplained RSA is controversial. In the present study, diagnostic and prognostic aspects were investigated.
Abstract:
METHOD: One hundred five nonpregnant patients with primary, 29 with secondary RSA, and 209 controls were investigated for IgG-ACA. Follow-up studies were done during pregnancy in 76 individuals. IgM-ACA were tested in a subset of patients.
RESULTS: Elevated ACA levels were significantly more frequent in both patient groups (26 and 24%) than in controls (16%). However, there was no correlation of ACA with various parameters including pregnancy outcome. In ACA-positive patients with successful pregnancy a significant decrease of ACA values during pregnancy was observed, while ACA remained high in aborting patients. IgG- and IgM-ACA correlated well.
CONCLUSIONS: Although the data from nonpregnant RSA patients does not allow diagnostic or prognostic conclusions to be drawn, sequential testing of ACA-positive individuals provides the possibility to foresee pregnancy outcome.
Citation Styles
Harvard Citation style: Melk, A., Mueller-Eckhardt, G., Polten, B., Lattermann, A., Heine, O. and Hoffmann, O. (1995) Diagnostic and Prognostic Significance of Anticardiolipin Antibodies in Patients With Recurrent Spontaneous Abortions, American Journal of Reproductive Immunology, 33(3), pp. 228-233. https://doi.org/10.1111/j.1600-0897.1995.tb00889.x
APA Citation style: Melk, A., Mueller-Eckhardt, G., Polten, B., Lattermann, A., Heine, O., & Hoffmann, O. (1995). Diagnostic and Prognostic Significance of Anticardiolipin Antibodies in Patients With Recurrent Spontaneous Abortions. American Journal of Reproductive Immunology. 33(3), 228-233. https://doi.org/10.1111/j.1600-0897.1995.tb00889.x
Keywords
ANTICARDIOLIPIN ANTIBODIES; ANTIPHOSPHOLIPID ANTIBODIES; AUTOANTIBODIES; FETAL LOSS; HABITUAL ABORTION; MISCARRIAGE; PREGNANCY WASTAGE; RECURRENT SPONTANEOUS ABORTION; (RSA); SYSTEMIC LUPUS-ERYTHEMATOSUS; WOMEN