Journal article

Publication year: 1994

Pages: 1097-1102

Journal: Journal of Hepatology

Volume number: 21

Issue number: 6

ISSN: 0169-5185

DOI Link: https://doi.org/10.1016/S0168-8278(05)80624-5

Publisher: Elsevier

Abstract: 
Serum concentrations of KBsAg, HBeAg and hepatitis B virus DNA were measured quantitatively before interferon treatment in 23 children (17 boys, 6 girls) suffering from chronic hepatitis B, and correlated to the outcome of the treatment. Five children remained HBsAg- and HBeAg-positive throughout the treatment and 6 months after the end of the treatment (non-responders), 12 children eliminated HBeAg but not HBsAg (partial responders) and six eliminated HBeAg and HBsAg (complete responders). The five non-responders had significantly higher initial HBsAg and HBeAg concentrations and significantly lower alanine aminotransferase levels than the partial or complete responders. The six complete responders had significantly lower HBsAg concentrations than the partial or non-responders, and seemed to be younger. No significant difference in HBV DNA levels was found in the three response groups. These data suggest that quantitative assays of HBsAg and HBeAg are particularly useful in selecting patients with chronic hepatitis B for interferon therapy. (C) Journal of Hepatology.

Harvard Citation style: Burczynska, B., Madalinski, K., Pawlowska, J., Woynarowski, M., Socha, J., Gerlich, W., et al. (1994) The value of quantitative measurement of HBeAg and HBsAg before interferon-α treatment of chronic hepatitis B in children, Journal of Hepatology, 21(6), pp. 1097-1102. https://doi.org/10.1016/S0168-8278(05)80624-5

APA Citation style: Burczynska, B., Madalinski, K., Pawlowska, J., Woynarowski, M., Socha, J., Gerlich, W., Willems, W., Wozniewicz, B., & Stachowski, J. (1994). The value of quantitative measurement of HBeAg and HBsAg before interferon-α treatment of chronic hepatitis B in children. Journal of Hepatology. 21(6), 1097-1102. https://doi.org/10.1016/S0168-8278(05)80624-5