Journal article

Publication year: 1994

Pages: 39-42

Journal: Clinical & Experimental Immunology

Volume number: 97

ISSN: 0009-9104

eISSN: 1365-2249

Publisher: Oxford University Press

Abstract: 
A specific effect of intravenous immune globulin (IVIG) on the outcome of pregnancy in patients with a history of habitual abortion has been postulated as an alternative to immunotherapy with allogeneic leucocytes. The results of different pilot studies have been promising, demonstrating a successful outcome of pregnancy in approximately 80% of treated patients. However, the evaluation and interpretation of the study results has to take into account that the probability of a successful pregnancy in women with a history of three spontaneous abortions is about 60% without treatment. Specific pharmacological effects therefore have to be verified in controlled studies in order to rule out psychological (placebo) effects. A specific therapeutic effect could not be verified in a German randomized, double-blind, multicentre trial in comparison to human albumin 5% which was used as a placebo. The result of another controlled study currently underway in the USA is expected.

Harvard Citation style: HEINE, O. and MUELLERECKHARDT, G. (1994) INTRAVENOUS IMMUNE GLOBULIN IN RECURRENT ABORTION, Clinical & Experimental Immunology, 97, pp. 39-42

APA Citation style: HEINE, O., & MUELLERECKHARDT, G. (1994). INTRAVENOUS IMMUNE GLOBULIN IN RECURRENT ABORTION. Clinical & Experimental Immunology. 97, 39-42.