Journal article

Cholinergic mechanisms in the neurocontrol of the cephalic aorta of the cephalopod Sepia officinalis L.


Authors listSchipp, R; Fiedler, A

Publication year1994

Pages149-157

JournalComparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology

Volume number107

Issue number1

ISSN0742-8413

DOI Linkhttps://doi.org/10.1016/1367-8280(94)90021-3

PublisherElsevier


Abstract
In dopamine (DA)-precontracted, ring-shaped muscle preparations of the cephalic aorta of Sepia officinalis L. acetylcholine (ACh) and several cholinomimetics showed vasodilatory effects. The pD(2)-values evaluated from the concentration-response curves reveal a vasodilatory potency range of: carbachol (pD(2) = 6.69) > ACh (pD(2) = 5.09) > muscarine (pD(2) = 4.09). The reduced action of nicotine results in a biphasic concentration-response curve that indicates a significantly lower intrinsic activity of this agonist. Under the ACh-antagonists applied, only tetraethylammonium (TEA) had a blocking effect (pA(2) = 5.46 TEA/ACh; pA(2) = 5.74 TEA/carbachol), whereas D-tubocurarirae, alpha-bungarotoxin (alpha-BTX), atropine and pirenzepine enhanced or did not block the vasodilatory action of ACh and carbachol. The results suggest the presence of an ''M-like'' receptor in the cepahlic aorta of Sepia. The putative neurotransmitter FMRFamide which mimicked the vasodilatory effects of the cholinomimetics showed the highest potency (pD(2) = 8.24). Its action could not be blocked by TEA and seems to be mediated by another receptor mechanism.



Citation Styles

Harvard Citation styleSchipp, R. and Fiedler, A. (1994) Cholinergic mechanisms in the neurocontrol of the cephalic aorta of the cephalopod Sepia officinalis L., Comparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology, 107(1), pp. 149-157. https://doi.org/10.1016/1367-8280(94)90021-3

APA Citation styleSchipp, R., & Fiedler, A. (1994). Cholinergic mechanisms in the neurocontrol of the cephalic aorta of the cephalopod Sepia officinalis L.. Comparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology. 107(1), 149-157. https://doi.org/10.1016/1367-8280(94)90021-3



Keywords


BLOOD-VESSELSINNERVATIONISOLATED HEARTOCTOPUS-DOFLEINI

Last updated on 2025-21-05 at 18:47