Journal article
Authors list: Schipp, R; Fiedler, A
Publication year: 1994
Pages: 149-157
Journal: Comparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology
Volume number: 107
Issue number: 1
ISSN: 0742-8413
DOI Link: https://doi.org/10.1016/1367-8280(94)90021-3
Publisher: Elsevier
Abstract:
In dopamine (DA)-precontracted, ring-shaped muscle preparations of the cephalic aorta of Sepia officinalis L. acetylcholine (ACh) and several cholinomimetics showed vasodilatory effects. The pD(2)-values evaluated from the concentration-response curves reveal a vasodilatory potency range of: carbachol (pD(2) = 6.69) > ACh (pD(2) = 5.09) > muscarine (pD(2) = 4.09). The reduced action of nicotine results in a biphasic concentration-response curve that indicates a significantly lower intrinsic activity of this agonist. Under the ACh-antagonists applied, only tetraethylammonium (TEA) had a blocking effect (pA(2) = 5.46 TEA/ACh; pA(2) = 5.74 TEA/carbachol), whereas D-tubocurarirae, alpha-bungarotoxin (alpha-BTX), atropine and pirenzepine enhanced or did not block the vasodilatory action of ACh and carbachol. The results suggest the presence of an ''M-like'' receptor in the cepahlic aorta of Sepia. The putative neurotransmitter FMRFamide which mimicked the vasodilatory effects of the cholinomimetics showed the highest potency (pD(2) = 8.24). Its action could not be blocked by TEA and seems to be mediated by another receptor mechanism.
Citation Styles
Harvard Citation style: Schipp, R. and Fiedler, A. (1994) Cholinergic mechanisms in the neurocontrol of the cephalic aorta of the cephalopod Sepia officinalis L., Comparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology, 107(1), pp. 149-157. https://doi.org/10.1016/1367-8280(94)90021-3
APA Citation style: Schipp, R., & Fiedler, A. (1994). Cholinergic mechanisms in the neurocontrol of the cephalic aorta of the cephalopod Sepia officinalis L.. Comparative Biochemistry and Physiology. Part C: Pharmacology, toxicology and endocrinology. 107(1), 149-157. https://doi.org/10.1016/1367-8280(94)90021-3
Keywords
BLOOD-VESSELS; INNERVATION; ISOLATED HEART; OCTOPUS-DOFLEINI