Journalartikel

Jahr der Veröffentlichung: 1992

Seiten: 27-33

Zeitschrift: Der Anaesthesist

Bandnummer: 41

Heftnummer: 1

ISSN: 0003-2417

Verlag: Springer

Abstract: 
The influence of two different methods of autologous transfusion, preoperative donor plasmapheresis (Abbott Autotrans) and postoperative autotransfusion (intraoperative blood salvage, Dideco Autotrans), on the intravascular hemostatic system was investigated. Forty-two patients undergoing total hip surgery and preoperative donor plasmapheresis were prospectively randomized into three groups. For substitution of blood loss, patients in group 1 (control group, n = 12) received in addition to cristalloids and colloids only homologous blood, group 2 (n = 14) autologous blood, and group 3 (n = 16) additionally intra- and postoperative autologous fresh frozen plasma (FFP). The investigation included blood parameters (hemoglobin, hematocrit, thrombocytes), clotting status (prothrombin time, plasma thromboplastin time, thrombin time, fibrinogen, plasminogen, and antithrombin III), and immunological methods such as fibrinopeptide A (FPA), thrombin-antithrombin III (TAT), and protein C. No significant difference was found with respect to total amount of infusion, intraoperative blood loss, autologous transfusion, and blood parameters. Excellent quality of the autologous FFP was demonstrated by investigation of the specimens before administration (Table 6). The autologous packed red cells showed high levels of TAT and FPA as an indicator of thrombin generation (Table 6). Their administration caused a significant increase in TAT and FPA levels in groups 2 and 3 compared to group 1 (Figs. 1 and 2). The effects of autotransfusion on the hemostic system could not be detected by normal clotting parameters, but only on immunological tests (Tables 3 and 5). The study indicates the advantage of combined administration of FFP and autologous blood in reducing homologous blood requirements and improving intravascular clotting status (Table 5). The immunological tests enlarge our diagnostic spectrum for coagulation, detecting prethrombotic conditions, and thromboembolic events.

Harvard-Zitierstil: MENGES, T., RUPP, D., VANLESSEN, A. and HEMPELMANN, G. (1992) EFFECTS ON COAGULATION PARAMETERS OF DIFFERENT METHODS OF AUTOLOGOUS BLOOD-TRANSFUSION, Der Anaesthesist, 41(1), pp. 27-33

APA-Zitierstil: MENGES, T., RUPP, D., VANLESSEN, A., & HEMPELMANN, G. (1992). EFFECTS ON COAGULATION PARAMETERS OF DIFFERENT METHODS OF AUTOLOGOUS BLOOD-TRANSFUSION. Der Anaesthesist. 41(1), 27-33.