Journal article

Publication year: 1991

Pages: 253-261

Journal: Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis

Volume number: 64

Issue number: 2

ISSN: 0049-3848

DOI Link: https://doi.org/10.1016/0049-3848(91)90124-F

Publisher: Elsevier

Abstract: 
In liver disorders alterations of the coagulation system are mainly due to a reduced synthesis of coagulation proteins. In addition, an enhanced intravascular consumption of coagulation factors is discussed controversely in liver diseases. By measuring factor IX(i)AT-and TAT-complexes we tried to find out, whether coagulation activation in liver patients leads to activation of the complete coagulation cascade followed by DIC or whether in some diseases a futile partial coagulation activation develops. In all liver diseases examined, elevated factor IX(i)AT-complexes were demonstrated, while TAT-complexes were only elevated in chronic active hepatitis, metabolic decompensated liver cirrhosis and in patients suffering from end stage liver disease. We conclude that all liver diseases examined lead to an activation of the coagulation cascade. A complete activation followed by DIC only occurs in patients with very severe liver disorders.

Harvard Citation style: KEMKESMATTHES, B., BLEYL, H. and MATTHES, K. (1991) COAGULATION ACTIVATION IN LIVER-DISEASES, Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis, 64(2), pp. 253-261. https://doi.org/10.1016/0049-3848(91)90124-F

APA Citation style: KEMKESMATTHES, B., BLEYL, H., & MATTHES, K. (1991). COAGULATION ACTIVATION IN LIVER-DISEASES. Thrombosis Research: Vascular Obstruction, Hemorrhage and Hemostasis. 64(2), 253-261. https://doi.org/10.1016/0049-3848(91)90124-F