Journal article

Publication year: 1991

Pages: 421-429

Journal: Comparative biochemistry and physiology. Part C: Comparative pharmacology

Volume number: 99

Issue number: 3

ISSN: 0742-8413

DOI Link: https://doi.org/10.1016/0742-8413(91)90266-V

Publisher: Elsevier

Abstract: 

1. Isometrical fixed ring-shaped preparations of the Ao. cephalica of Sepia officinalis L. (resting tension 3.5 cN) showed by high amplification of transducer mediated contractory signals a weak autorhythmical activity, which could be evaluated as from small muscle fibres of T. adventitia and mesangium.

2. By pharmacological bioassay using native and synthetic agonists and blocking substances a catecholamine receptor could be revealed resembling more the alpha-type of vertebrates.

3. The potency range: DA (pD2 = 5.69) > NA (pD2 = 4.52) > A (pD2 = 4.30) is contrary to that of the heart.

4. FMRFamide and analogues, which could be found immunohistochemically within the peripheral vessel wall as well as 5-HT-induced vasodilatations in DA-precontracted preparations-contrary to these effects and their positive inotropic action on the heart.

5. The findings are compared with in vivo results.

Harvard Citation style: SCHIPP, R., JAKOBS, P. and FIEDLER, A. (1991) MONOAMINERGIC PEPTIDERGIC INTERACTIONS IN NEUROREGULATORY CONTROL OF THE CEPHALIC AORTA IN SEPIA-OFFICINALIS L (CEPHALOPODA), Comparative biochemistry and physiology. Part C: Comparative pharmacology, 99(3), pp. 421-429. https://doi.org/10.1016/0742-8413(91)90266-V

APA Citation style: SCHIPP, R., JAKOBS, P., & FIEDLER, A. (1991). MONOAMINERGIC PEPTIDERGIC INTERACTIONS IN NEUROREGULATORY CONTROL OF THE CEPHALIC AORTA IN SEPIA-OFFICINALIS L (CEPHALOPODA). Comparative biochemistry and physiology. Part C: Comparative pharmacology. 99(3), 421-429. https://doi.org/10.1016/0742-8413(91)90266-V