Journal article

Publication year: 1990

Pages: 71-78

Journal: Comparative biochemistry and physiology. Part C: Comparative pharmacology

Volume number: 97

Issue number: 1

ISSN: 0742-8413

DOI Link: https://doi.org/10.1016/0742-8413(90)90174-8

Publisher: Elsevier

Abstract: 

1. The chronotropic and inotropic effects of biogenic monoamines were examined on the isolated and perfused branchial heart of the common cuttlefish Sepia officinalis (L.).

2. Adrenaline, noradrenaline and dopamine caused concentration-dependent increases in pressure amplitude, dopamine being 100-fold less potent than adrenaline and noradrenaline. The catecholamines hardly affected frequency.

3. Octopamine, histamine and GABA did not influence normal heartbeat.

4. Serotonin was either ineffective or produced variable responses, whereby the efficacy of the substance was not graded to the concentrations applied. It is supposed that serotonin is not involved in branchial heart regulation.

5. The actions of different adrenergic agonists and antagonists indicate the presence of a myocardial adrenoceptor which closely resembles the alpha-1-type.

Harvard Citation style: FIEDLER, A. and SCHIPP, R. (1990) THE EFFECTS OF BIOGENIC MONOAMINES AND RELATED AGONISTS AND ANTAGONISTS ON THE ISOLATED, PERFUSED BRANCHIAL HEART OF SEPIA-OFFICINALIS L (CEPHALOPODA), Comparative biochemistry and physiology. Part C: Comparative pharmacology, 97(1), pp. 71-78. https://doi.org/10.1016/0742-8413(90)90174-8

APA Citation style: FIEDLER, A., & SCHIPP, R. (1990). THE EFFECTS OF BIOGENIC MONOAMINES AND RELATED AGONISTS AND ANTAGONISTS ON THE ISOLATED, PERFUSED BRANCHIAL HEART OF SEPIA-OFFICINALIS L (CEPHALOPODA). Comparative biochemistry and physiology. Part C: Comparative pharmacology. 97(1), 71-78. https://doi.org/10.1016/0742-8413(90)90174-8