Journal article

Publication year: 1989

Pages: 151-154

Journal: Vox Sanguinis

Volume number: 56

Issue number: 3

ISSN: 0042-9007

eISSN: 1423-0410

DOI Link: https://doi.org/10.1111/j.1423-0410.1989.tb02018.x

Publisher: Wiley

Abstract: 
Intravenous immunoglobulin (IVIG) treatment was attempted as a novel therapeutic approach for unexplained recurrent spontaneous abortions (RSA) occurring in the first trimester of pregnancy. Twenty women with a history of RSA were treated with IVIG during pregnancy. Therapy was commenced at week 5 of gestation with 1 dose of 0.5-0.6 g IVIG/kg body weight. Infusions were repeated every 3 weeks (0.3-0.4 g/kg) nd terminated by week 22 to 24. Of 20 women, 11 delivered healthy infants at term. 5 women are still pregnant, 3 in the third trimester. Only 3 patients suffered abortions and 1 presented with ectopic pregnancy. The overall success rate was 82-86%. Thus, the therapeutic effect of IVIG is comparable to that of the conventional transfusion/vaccination regimen with allogeneic leukocytes, but avoids the risk of transmission of infections and/or HLA immunization, has no major adverse effects and is applicable to ''nonresponders''.

Harvard Citation style: MUELLERECKHARDT, G., HEINE, O., NEPPERT, J., KUNZEL, W. and MUELLERECKHARDT, C. (1989) PREVENTION OF RECURRENT SPONTANEOUS-ABORTION BY INTRAVENOUS IMMUNOGLOBULIN, Vox Sanguinis, 56(3), pp. 151-154. https://doi.org/10.1111/j.1423-0410.1989.tb02018.x

APA Citation style: MUELLERECKHARDT, G., HEINE, O., NEPPERT, J., KUNZEL, W., & MUELLERECKHARDT, C. (1989). PREVENTION OF RECURRENT SPONTANEOUS-ABORTION BY INTRAVENOUS IMMUNOGLOBULIN. Vox Sanguinis. 56(3), 151-154. https://doi.org/10.1111/j.1423-0410.1989.tb02018.x