Journalartikel

Jahr der Veröffentlichung: 1988

Seiten: 83-94

Zeitschrift: Cancer Genetics and Cytogenetics

Bandnummer: 31

Heftnummer: 1

ISSN: 0165-4608

DOI Link: https://doi.org/10.1016/0165-4608(88)90015-5

Verlag: Elsevier

Abstract: 
Fragile sites on lymphocyte chromosomes of 20 patients with neuroblastoma of different clinical stages and histologic differentiation were studied. A hitherto unknown break in the band p13.1 of chromosome #1 was found in a frequency of 3%-15% in nine cases. The same phenomenon was observed in three members of neuroblastoma family. In another instance, this fragile site was seen in the mother of a patient. Fragile sites were expressed when cells were cultured in folate-deprived medium and could be slightly enhanced in frequency by aphidicolin. Additional aphidicolin induced possible fragile sites hitherto unknown or not yet accepted by the HGM 8 were detected.

Harvard-Zitierstil: RUDOLPH, B., HARBOTT, J. and LAMPERT, F. (1988) FRAGILE SITES AND NEURO-BLASTOMA - FRAGILE SITE AT 1P13.1 AND OTHER POINTS ON LYMPHOCYTE CHROMOSOMES FROM PATIENTS AND FAMILY MEMBERS, Cancer Genetics and Cytogenetics, 31(1), pp. 83-94. https://doi.org/10.1016/0165-4608(88)90015-5

APA-Zitierstil: RUDOLPH, B., HARBOTT, J., & LAMPERT, F. (1988). FRAGILE SITES AND NEURO-BLASTOMA - FRAGILE SITE AT 1P13.1 AND OTHER POINTS ON LYMPHOCYTE CHROMOSOMES FROM PATIENTS AND FAMILY MEMBERS. Cancer Genetics and Cytogenetics. 31(1), 83-94. https://doi.org/10.1016/0165-4608(88)90015-5