Journal article

Publication year: 1987

Pages: 251-258

Journal: Comparative biochemistry and physiology. Part C: Comparative pharmacology

Volume number: 87

Issue number: 2

ISSN: 1532-0456

eISSN: 1878-1659

DOI Link: https://doi.org/10.1016/0742-8413(87)90005-3

Publisher: Elsevier

Abstract: 
1. Effects of noradrenaline and the related compounds adrenaline, dopamine, octopamine, tyramine, clonidine and isoprenaline were studied in isolated heart preparations from the cuttlefish Sepia officinalis L. 2. All analogues produced a positive inotropic affect, with noradrenaline being the most potent substance. The chronotropic effects of the tested compounds differed widely. 3. The action of substances of the phenylethanolamine group were not antagonized by propanolol but were partly antagonized by phentolamine. 4. Serotonin and its analogues also produced cardio-excitation. These effects were blocked by cyproheptadine but not by methysergide. 5. These results indicate the presence of two different receptors in the Sepia myocardium: one type reacting with noradrenaline most effectively and a second type being stimulated by serotonin.

Harvard Citation style: Kling, G. and Schipp, R. (1987) Effects of biogenic amines and related agonists and antagonists on the isolated heart of the common cuttlefish Sepia Officinalis L., Comparative biochemistry and physiology. Part C: Comparative pharmacology, 87(2), pp. 251-258. https://doi.org/10.1016/0742-8413(87)90005-3

APA Citation style: Kling, G., & Schipp, R. (1987). Effects of biogenic amines and related agonists and antagonists on the isolated heart of the common cuttlefish Sepia Officinalis L.. Comparative biochemistry and physiology. Part C: Comparative pharmacology. 87(2), 251-258. https://doi.org/10.1016/0742-8413(87)90005-3