Journal article

ASSAY FOR THYROID GROWTH STIMULATING IMMUNOGLOBULINS - STIMULATION OF [H-3] THYMIDINE INCORPORATION INTO ISOLATED THYROID-FOLLICLES BY TSH, EGF, AND IMMUNOGLOBULINS FROM GOITROUS PATIENTS IN AN IODINE-DEFICIENT REGION


Authors listSCHATZ, H; PSCHIERERBERG, K; NICKEL, JA; BAR, R; MULLER, F; BRETZEL, RG; MULLER, H; STRACKE, H

Publication year1986

Pages523-530

JournalActa endocrinologica

Volume number112

Issue number4

ISSN0001-5598

DOI Linkhttps://doi.org/10.1530/acta.0.1120523

PublisherScandinavian Univ. Press


Abstract
Estimations were carried out of [3H]thymidine incorporation during culture of isolated porcine thyroid follicles in the presence of standard TSH or epidermal growth factor (EGF) both alone and together with anti-TSH or anti-EGF serum, and of immunoglobulins fractionated from the sera of patients from our endemic goitre area with iodine deficiency. A significant stimulation of thymidine incorporation was exerted by TSH when thyroglobulin was present in the culture medium, and also by EGF. TSH stimulation was abolished by anti-TSH serum, in contrast to the effect of EGF. Anti-EGF serum, on the other hand, blocked the effect of EGF, but not that of TSH. The sera of 20 out of 72 patients (27%) with euthyroid goitre (not operated on) and of ten out of 26 patients (38%) with recurrent euthryoid goitre contained immunoglobulins stimulating thyroid growth (TGI). There was no correlation of TGI with other thyroid antibodies. TGI have to be regarded as a pathogenetic factor of euthyroid goitre also in patients from an endemic region especially in recurrent cases.



Citation Styles

Harvard Citation styleSCHATZ, H., PSCHIERERBERG, K., NICKEL, J., BAR, R., MULLER, F., BRETZEL, R., et al. (1986) ASSAY FOR THYROID GROWTH STIMULATING IMMUNOGLOBULINS - STIMULATION OF [H-3] THYMIDINE INCORPORATION INTO ISOLATED THYROID-FOLLICLES BY TSH, EGF, AND IMMUNOGLOBULINS FROM GOITROUS PATIENTS IN AN IODINE-DEFICIENT REGION, Acta endocrinologica, 112(4), pp. 523-530. https://doi.org/10.1530/acta.0.1120523

APA Citation styleSCHATZ, H., PSCHIERERBERG, K., NICKEL, J., BAR, R., MULLER, F., BRETZEL, R., MULLER, H., & STRACKE, H. (1986). ASSAY FOR THYROID GROWTH STIMULATING IMMUNOGLOBULINS - STIMULATION OF [H-3] THYMIDINE INCORPORATION INTO ISOLATED THYROID-FOLLICLES BY TSH, EGF, AND IMMUNOGLOBULINS FROM GOITROUS PATIENTS IN AN IODINE-DEFICIENT REGION. Acta endocrinologica. 112(4), 523-530. https://doi.org/10.1530/acta.0.1120523


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