Journal article
Authors list: SCHATZ, H; PSCHIERERBERG, K; NICKEL, JA; BAR, R; MULLER, F; BRETZEL, RG; MULLER, H; STRACKE, H
Publication year: 1986
Pages: 523-530
Journal: Acta endocrinologica
Volume number: 112
Issue number: 4
ISSN: 0001-5598
DOI Link: https://doi.org/10.1530/acta.0.1120523
Publisher: Scandinavian Univ. Press
Abstract:
Estimations were carried out of [3H]thymidine incorporation during culture of isolated porcine thyroid follicles in the presence of standard TSH or epidermal growth factor (EGF) both alone and together with anti-TSH or anti-EGF serum, and of immunoglobulins fractionated from the sera of patients from our endemic goitre area with iodine deficiency. A significant stimulation of thymidine incorporation was exerted by TSH when thyroglobulin was present in the culture medium, and also by EGF. TSH stimulation was abolished by anti-TSH serum, in contrast to the effect of EGF. Anti-EGF serum, on the other hand, blocked the effect of EGF, but not that of TSH. The sera of 20 out of 72 patients (27%) with euthyroid goitre (not operated on) and of ten out of 26 patients (38%) with recurrent euthryoid goitre contained immunoglobulins stimulating thyroid growth (TGI). There was no correlation of TGI with other thyroid antibodies. TGI have to be regarded as a pathogenetic factor of euthyroid goitre also in patients from an endemic region especially in recurrent cases.
Citation Styles
Harvard Citation style: SCHATZ, H., PSCHIERERBERG, K., NICKEL, J., BAR, R., MULLER, F., BRETZEL, R., et al. (1986) ASSAY FOR THYROID GROWTH STIMULATING IMMUNOGLOBULINS - STIMULATION OF [H-3] THYMIDINE INCORPORATION INTO ISOLATED THYROID-FOLLICLES BY TSH, EGF, AND IMMUNOGLOBULINS FROM GOITROUS PATIENTS IN AN IODINE-DEFICIENT REGION, Acta endocrinologica, 112(4), pp. 523-530. https://doi.org/10.1530/acta.0.1120523
APA Citation style: SCHATZ, H., PSCHIERERBERG, K., NICKEL, J., BAR, R., MULLER, F., BRETZEL, R., MULLER, H., & STRACKE, H. (1986). ASSAY FOR THYROID GROWTH STIMULATING IMMUNOGLOBULINS - STIMULATION OF [H-3] THYMIDINE INCORPORATION INTO ISOLATED THYROID-FOLLICLES BY TSH, EGF, AND IMMUNOGLOBULINS FROM GOITROUS PATIENTS IN AN IODINE-DEFICIENT REGION. Acta endocrinologica. 112(4), 523-530. https://doi.org/10.1530/acta.0.1120523