Journal article

Publication year: 1986

Pages: 67-72

Journal: Blut

Volume number: 52

Issue number: 2

ISSN: 0006-5242

Open access status: Bronze

DOI Link: https://doi.org/10.1007/BF00321069

Publisher: Springer

Abstract: 
Sixteen commercially available immunoglobulins (Ig) and 5 anti-Rho(D) hyperimmune globulins were investigated for immune phagocytosis inhibition (IPI) factors as well as for T, B lymphocytotoxic and monocytotoxic antibodies. All Ig contained IPI factors with lowest inhibitory IgG concentrations ranging from 0.08 to 50 mg/ml. Pepsin-digested Ig was noninhibitory. IPI factors in anti-D preparations were uniformly high (inhibitory IgG concentrations 0.6-2.5 mg/ml). Cytotoxic antibodies against T, B lymphocytes and monocytes were found in 2,2 and 7 products, respectively. Since we have recently shown that IPI is caused by antibodies against major histocompatibility complex antigens, most likely HLA, the hypothesis is put forward that IPI factors in Ig are HLA-related, cytotoxic as well as noncytotoxic antibodies which act via Fc receptor blockade of human monocytes.

Harvard Citation style: NEPPERT, J., CLEMENS, M. and MUELLERECKHARDT, C. (1986) IMMUNE PHAGOCYTOSIS INHIBITION BY COMMERCIAL IMMUNOGLOBULINS, Blut, 52(2), pp. 67-72. https://doi.org/10.1007/BF00321069

APA Citation style: NEPPERT, J., CLEMENS, M., & MUELLERECKHARDT, C. (1986). IMMUNE PHAGOCYTOSIS INHIBITION BY COMMERCIAL IMMUNOGLOBULINS. Blut. 52(2), 67-72. https://doi.org/10.1007/BF00321069