Journalartikel

Jahr der Veröffentlichung: 1984

Seiten: 486-489

Zeitschrift: Transfusion

Bandnummer: 24

Heftnummer: 6

ISSN: 0041-1132

eISSN: 1537-2995

DOI Link: https://doi.org/10.1046/j.1537-2995.1984.24685066806.x

Verlag: Wiley

Abstract: 
To investigate the clinical significance of HLA determinants expressed on red cells (RBC), 51Cr survival studies were carried out in 6 women (4 healthy individuals, 2 patients with solid carcinoma) immunized against HLA antigens by pregnancy or blood transfusions, respectively. Donors were selected who were compatible in typical RBC antigen systems assayed by conventional techniques but were mismatched for the HLA antigens in question. Crossmatches were also performed with RBC, as well as with lymphocytes, by means of a radioimmune anti-IgG test (RIAT). RBC survival was shortened in all cases. The mean life-span of RBC depended on antigen specificity rather than on the antibody strength. HLA incompatibility of RBC could be monitored by the RIAT in all donor/recipient pairs. A shortened mean life-span of RBC is to be expected by HLA antibodies, especially when HLA-B7 is involved, but the severity of an in vivo immune reaction in HLA incompatible transfusions cannot be predicted from the in vitro tests used.

Harvard-Zitierstil: PANZER, S., MUELLERECKHARDT, G., SALAMA, A., STRAUSS, B., KIEFEL, V. and MUELLERECKHARDT, C. (1984) THE CLINICAL-SIGNIFICANCE OF HLA ANTIGENS ON RED-CELLS - SURVIVAL STUDIES IN HLA-SENSITIZED INDIVIDUALS, Transfusion, 24(6), pp. 486-489. https://doi.org/10.1046/j.1537-2995.1984.24685066806.x

APA-Zitierstil: PANZER, S., MUELLERECKHARDT, G., SALAMA, A., STRAUSS, B., KIEFEL, V., & MUELLERECKHARDT, C. (1984). THE CLINICAL-SIGNIFICANCE OF HLA ANTIGENS ON RED-CELLS - SURVIVAL STUDIES IN HLA-SENSITIZED INDIVIDUALS. Transfusion. 24(6), 486-489. https://doi.org/10.1046/j.1537-2995.1984.24685066806.x