Journalartikel

Jahr der Veröffentlichung: 1982

Seiten: 97-100

Zeitschrift: International archives of allergy and applied immunology

Bandnummer: 68

Heftnummer: 2

ISSN: 0020-5915

DOI Link: https://doi.org/10.1159/000233075

Verlag: Karger

Abstract: 
Palytoxin (PTX) is a potent releaser of histamine from rat mast cells. The concentration response curve is bell-shaped with its range between 0.05 ng/ml-5 .mu.g/ml and its maximum at 50 ng/ml. The release of histamine by PTX is specific because heat-inactivated (50.degree. C) mast cells are insensitive to PTX, and extracellular Ca is essential. Removal of extracellular K and the presence of borate shifts the curve to the left by a factor of 10. At higher concentrations (5 .mu.g/ml), PTX inhibits the release of histamine due to compound 48/80, MCD[most cell degranulating peptide]-peptide, Con-A [concanalvalin A], ionophore A-23187 [calcimycin] and PTX itself.

Harvard-Zitierstil: CHHATWAL, G., AHNERTHILGER, G., BERESS, L. and HABERMANN, E. (1982) PALYTOXIN BOTH INDUCES AND INHIBITS THE RELEASE OF HISTAMINE FROM RAT MAST-CELLS, INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 68(2), pp. 97-100. https://doi.org/10.1159/000233075

APA-Zitierstil: CHHATWAL, G., AHNERTHILGER, G., BERESS, L., & HABERMANN, E. (1982). PALYTOXIN BOTH INDUCES AND INHIBITS THE RELEASE OF HISTAMINE FROM RAT MAST-CELLS. INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY. 68(2), 97-100. https://doi.org/10.1159/000233075