Journalartikel

Jahr der Veröffentlichung: 1978

Seiten: 301-315

Zeitschrift: Journal of Cancer Research and Clinical Oncology

Bandnummer: 91

Heftnummer: 3

DOI Link: https://doi.org/10.1007/BF00312292

Verlag: Springer

Abstract: 
About 7000 animals of 65 genotypes of xiphophorine fish were treated with the direct acting chemical carcinogen MNU; 10-3 M: times for 1 h in 2 wk intervals, to find whether susceptibility for development of fibrosarcomas and rhabdomyosarcomas is directly related to genotype. A genotype specific susceptibility was found, ranging from zero to about 9%. The highest susceptibilities were found in certain backcross hybrids involving Platypoecilus variatus/Xiphophorus helleri hybrids and X. helleri as the recurrent parent. These genotypes were further analyzed. P. variatus and X. helleri, as well as their F1 were insusceptible; while from the 2 backcrosses tested, namely BC1, BC4 and BC15, BC1 and BC4, were susceptible, but BC15 was insusceptible. The results are interpreted on the basis of the assumption that the differential susceptibility is a function of the type of control of a tumor gene (Tu-Fi-Rh) endogenous to P. variatus and involved in development of fibrosarcomas and rhabdomyosarcomas. In P. variatus and the F1 the Tu-Fi-Rh is controlled by repressing genes (R-genes), linked and nonlinked to Tu-Fi-Rh. Because simultaneous mutation of both R genes following treatment with MNU is an extremely unlikely event, these genotypes have an extremely low susceptibility. In BC1 and BC4 the nonlinked R-genes become eliminated and only the linked R-gene remains for repression of Tu-Fi-Rh. This condition confers a high degree of susceptibility, because 1 single mutation may lead to impairment of the R-gene and Tu-Fi-Rh-mediated formation of fibrosarcomas and rhabdomyosarcomas. In BC15, Tu-Fi-Rh also becomes eliminated, resulting in a loss of susceptibility. In the xiphophophorine fish the susceptibility for responding to MNU-treatment with the development of fibrosarcomas and rhabdomyosarcomas is related directly to the genotype.

Harvard-Zitierstil: Schwab, M., Abdo, S., Ahuja, M., Kollinger, G., Anders, A., Anders, F., et al. (1978) Genetics of susceptibility in the platyfish/swordtail tumor system to develop fibrosarcoma and rhabdomyosarcoma following treatment with N-methyl-N-nitrosourea (MNU), Journal of Cancer Research and Clinical Oncology, 91(3), pp. 301-315. https://doi.org/10.1007/BF00312292

APA-Zitierstil: Schwab, M., Abdo, S., Ahuja, M., Kollinger, G., Anders, A., Anders, F., & Frese, K. (1978). Genetics of susceptibility in the platyfish/swordtail tumor system to develop fibrosarcoma and rhabdomyosarcoma following treatment with N-methyl-N-nitrosourea (MNU). Journal of Cancer Research and Clinical Oncology. 91(3), 301-315. https://doi.org/10.1007/BF00312292