Journal article

Publication year: 2000

Pages: 173-180

Journal: Cancer Immunology, Immunotherapy

Volume number: 49

Issue number: 3

ISSN: 0340-7004

DOI Link: https://doi.org/10.1007/s002620050617

Publisher: Springer

Abstract: 
Fifteen patients with refractory Hodgkin's disease were treated in a dose-escalation trial with the bispecific monoclonal antibody (bi-mAb) HRS-3/A9, which is directed against the Fc gamma receptor III (CD16 antigen) and the Hodgkin's-associated CD30 antigen. Treatment consisted of four cycles of four bi-mAb infusions given over 1 h every 3-4 days at different dose levels ranging fi-om 1 mg/m(2) to 64 mg/m(2) Measurable serum levels (above 0.1 mu g/ml) of circulating bi-mAb could be detected in patients treated with doses above 4 mg/m(2), reaching peak levels of 9.5 mu g/ml immediately after the end of antibody infusion on the highest dose level. Bi-mAb elimination corresponded to second-order kinetics with a terminal half-life time (t(1/2,beta)) of 28-32 h. Bi-mAb treatment induced the occurrence of human anti-(mouse Ig) antibodies (HAMA) in 6 out of 13 patients initially testing negative. All 6 patients not only developed anti-isotypic anti-(mouse IE) but also antiidiotypic and anti-anti-idiotypic antibodies. While no consistent changes of peripheral blood cell counts, or of any lymphocyte subpopulation including natural killer (NK) cells, has been observed, 4 out of 6 evaluable patients treated with doses of at least 4 mg/m2 showed an increase of NK cell activity within 2 weeks after treatment, which lasted for a maximum of 12 weeks. Circulating amounts of soluble CD30 antigen could be detected in the serum of 6 patients. However, like the results and time courses of all the other immunological parameters evaluated, this was not predictive for treatment outcome.

Harvard Citation style: Renner, C., Hartmann, F., Jung, W., Deisting, C., Juwana, M. and Pfreundschuh, M. (2000) Initiation of humoral and cellular immune responses in patients with refractory Hodgkin's disease by treatment with an anti-CD16/CD30 bispecific antibody, Cancer Immunology, Immunotherapy, 49(3), pp. 173-180. https://doi.org/10.1007/s002620050617

APA Citation style: Renner, C., Hartmann, F., Jung, W., Deisting, C., Juwana, M., & Pfreundschuh, M. (2000). Initiation of humoral and cellular immune responses in patients with refractory Hodgkin's disease by treatment with an anti-CD16/CD30 bispecific antibody. Cancer Immunology, Immunotherapy. 49(3), 173-180. https://doi.org/10.1007/s002620050617