Journal article
Authors list: EFSA CEP Panel; Lambre, Claude; Barat Baviera, Jose Manuel; Bolognesi, Claudia; Cocconcelli, Pier Sandro; Crebelli, Riccardo; Gott, David Michael; Grob, Konrad; Lampi, Evgenia; Mengelers, Marcel; Mortensen, Alicja; Riviere, Gilles; Steffensen, Inger-Lise; Tlustos, Christina; Van Loveren, Henk; Vernis, Laurence; Zorn, Holger; Roos, Yrjoe; Fernandez-Fraguas, Cristina; Gomes, Ana; Liu, Yi; Chesson, Andrew
Publication year: 2024
Journal: EFSA Journal
Volume number: 22
Issue number: 1
eISSN: 1831-4732
DOI Link: https://doi.org/10.2903/j.efsa.2024.8513
Publisher: Wiley
Abstract:
The food enzyme phosphoinositide phospholipase C (1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase EC 3.1.4.11.) is produced with the genetically modified Pseudomonas fluorescens strain PIC by DSM Food specialties B.V. The genetic modifications do not give rise to safety concerns. The food enzyme is free from viable cells of the production organism and its DNA. It is intended to be used in the processing of fats and oils for the production of refined edible fats and oils by degumming. Since residual amounts of the total organic solids are removed by the washing and purification steps applied during degumming, dietary exposure estimation and toxicity testing were considered unnecessary. A search for the similarity of the amino acid sequence of the food enzyme to known allergens was made and no matches were found. The Panel considered that the risk of allergic reactions by dietary exposure cannot be excluded, but the likelihood for this to occur is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns under the intended conditions of use.
Citation Styles
Harvard Citation style: EFSA CEP Panel, Lambre, C., Barat Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., et al. (2024) Safety evaluation of the food enzyme phosphoinositide phospholipase C from the genetically modified Pseudomonas fluorescens strain PIC, EFSA Journal, 22(1), Article e8513. https://doi.org/10.2903/j.efsa.2024.8513
APA Citation style: EFSA CEP Panel, Lambre, C., Barat Baviera, J., Bolognesi, C., Cocconcelli, P., Crebelli, R., Gott, D., Grob, K., Lampi, E., Mengelers, M., Mortensen, A., Riviere, G., Steffensen, I., Tlustos, C., Van Loveren, H., Vernis, L., Zorn, H., Roos, Y., Fernandez-Fraguas, C., ...Chesson, A. (2024). Safety evaluation of the food enzyme phosphoinositide phospholipase C from the genetically modified Pseudomonas fluorescens strain PIC. EFSA Journal. 22(1), Article e8513. https://doi.org/10.2903/j.efsa.2024.8513
