Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens - Research portal of Justus Liebig University Giessen:

Journal article

Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens

Authors list: Diener, M; Bridges, RJ; Knobloch, SF; Rummel, W

Publication year: 1988

Pages: 74-78

Journal: Naunyn-Schmiedeberg's Archives of Pharmacology

Volume number: 337

Issue number: 1

ISSN: 0028-1298

eISSN: 1432-1912

DOI Link: https://doi.org/10.1007/BF00169480

Publisher: Springer

Abstract:
Two preparations of rat colon descendens were used in order to localize the action sites of iloprost and prostaglandin E2 (PGE2). One preparation, the mucosa-submucosa preparation contained the submucosal and mucosal plexus whereas for the mucosa preparation in addition the submucosa with the submucosal plexus was removed. Iloprost (10-6 mol .cntdot. l-1) caused an increase in short-circuit current (Isc), potential difference (Pd) and tissue conductance (Gt) of the mucosa-submucosa preparation reflecting net Cl- secreted as confirmed by unidirectional ion flux measurements. The Cl- secretion was due to an increase in JsmCl and a decrease in JmsCl. These effects were completely abolished by addition of 5 .times. 10-5 mol .cntdot. l-1 atropine. Iloprost had only small and inconsistent effects in the mucosa preparation. In contrast PGE2 (10-6 mol .cntdot. l-1) increased Isc, Pd and Gt due to Cl- secretion in both preparations. The Cl- secretion was caused by an increase in JsmCl and a decrease in JmsCl. Only the PGE2 effect in the mucosa-submucosa preparation but not in the mucosa preparation was inhibited by about 50% by atropine. The results suggest that the prostacyclin derivative iloprost induces a Cl- secretion only by an activation of submucosal neurons whereas PGE2 acts both on the epithelium and the submucosal plexus. The neuronal effects of prostaglandins appears to be, at least in part, mediated by muscarinic receptors.

Authors/Editors

- Uni.-Prof. Dr. Martin Heinz Diener

Citation Styles

Harvard Citation style: Diener, M., Bridges, R., Knobloch, S. and Rummel, W. (1988) Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens, Naunyn-Schmiedeberg's Archives of Pharmacology, 337(1), pp. 74-78. https://doi.org/10.1007/BF00169480

APA Citation style: Diener, M., Bridges, R., Knobloch, S., & Rummel, W. (1988). Neuronally mediated and direct effects of prostaglandins on ion transport in rat colon descendens. Naunyn-Schmiedeberg's Archives of Pharmacology. 337(1), 74-78. https://doi.org/10.1007/BF00169480