Journal article

Publication year: 1988

Pages: 217-225

Journal: European Journal of Pharmacology

Volume number: 152

Issue number: 3

ISSN: 0014-2999

eISSN: 1879-0712

DOI Link: https://doi.org/10.1016/0014-2999(88)90716-9

Publisher: Elsevier

Abstract: 
The action of loperamide on the ion secretion evoked in rat colon descendens by electric field stimulation of enteric neurons, on the Ca2+-dependent secretion due to carbachol, and on the cAMP-mediated secretion elicited by forskolin was studied. Loperamide blocked all three types of secretion, but about 10 times higher concentrations of the drug were necessary to block the secretion caused by forskolin than to block the secretion mediated neuronally or by Ca2+. All the effects of loperamide were mimicked by trifluoperazine, a calmodulin antagonist. Neither morphine nor the Ca2+ channel blocker, verapamil, mimicked the effects of loperamide on ion transport. Therefore it seems reasonable to conclude that the antisecretory action of loperamide in the rat colon is caused by a block of the calmodulin system.

Harvard Citation style: Diener, M., Knobloch, S. and Rummel, W. (1988) Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon, European Journal of Pharmacology, 152(3), pp. 217-225. https://doi.org/10.1016/0014-2999(88)90716-9

APA Citation style: Diener, M., Knobloch, S., & Rummel, W. (1988). Action of loperamide on neuronally mediated and Ca2+- or cAMP-mediated secretion in rat colon. European Journal of Pharmacology. 152(3), 217-225. https://doi.org/10.1016/0014-2999(88)90716-9