Journal article

Publication year: 1992

Pages: 781-788

Journal: Gastroenterology

Volume number: 103

Issue number: 3

ISSN: 0016-5085

DOI Link: https://doi.org/10.1016/0016-5085(92)90006-K

Publisher: Elsevier

Abstract: 

The effect of prostaglandin D₂ (PGD₂) on ion transport across the mucosa of the descending colon was studied in rats. PGD₂ dose-dependently decreased baseline short-circuit current of mucosa-submucosal preparations mounted either in the Ussing chamber or mounted as an everted sac. However, with the everted sac technique, the tissue was about 1000 times more sensitive to PGD₂. Concomitant with the decrease in short-circuit current, PGD₂ increased the mucosal-to-serosal fluxes of sodium and chloride and decreased the serosal-tomucosal flux of chloride. PGD₂ inhibited the secretory action of the PGI₂ analogue iloprost, PGD_2α, and neurotensin. The action of these secretagogues was dependent on the presence of the submucosal plexus. In contrast, PGD₂ had no effect on the increase in short-circuit current caused by PGD₂, substance P, or serotonin, the actions of which were not dependent on the presence of the submucosal plexus. The results indicate that the action site of the antisecretory mechanism of PGD₂ is localized in the secretomotor neurons.

Harvard Citation style: Goerg, K., Wanitschke, R., Diener, M. and Rummel, W. (1992) Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2, Gastroenterology, 103(3), pp. 781-788. https://doi.org/10.1016/0016-5085(92)90006-K

APA Citation style: Goerg, K., Wanitschke, R., Diener, M., & Rummel, W. (1992). Inhibition of neuronally mediated secretion in rat colonic mucosa by prostaglandin D2. Gastroenterology. 103(3), 781-788. https://doi.org/10.1016/0016-5085(92)90006-K