Conference paper

High-throughput multi-dimensional scaling (HiT-MDS) for cDNA-array expression data


Authors listStrickert, M; Teichmann, S; Sreenivasulu, N; Seiffert, U

Publication year2005

Pages625-633

JournalLecture notes in computer science

Volume number3696

ISSN0302-9743

ISBN3-540-28752-3

eISSN1611-3349

DOI Linkhttps://doi.org/10.1007/11550822_97

Conference15th International Conference on Artificial Neural Networks (ICANN 2005)

PublisherSpringer

Title of seriesLecture Notes in Computer Science


Abstract
Multidimensional Scaling (MDS) is a powerful dimension reduction technique for embedding high-dimensional data into a low-dimensional target space. Thereby, the distance relationships in the source are reconstructed in the target space as best as possible according to a given embedding criterion. Here, a new stress function with intuitive properties and a very good convergence behavior is presented. Optimization is combined with an efficient implementation for calculating dynamic distance matrix correlations, and the implementation can be transferred to other related algorithms. The suitability of the proposed MDS for high-throughput data (HiT-MDS) is studied in applications to macroarray analysis for up to 12,000 genes.



Authors/Editors




Citation Styles

Harvard Citation styleStrickert, M., Teichmann, S., Sreenivasulu, N. and Seiffert, U. (2005) High-throughput multi-dimensional scaling (HiT-MDS) for cDNA-array expression data, Lecture notes in computer science, 3696, pp. 625-633. https://doi.org/10.1007/11550822_97

APA Citation styleStrickert, M., Teichmann, S., Sreenivasulu, N., & Seiffert, U. (2005). High-throughput multi-dimensional scaling (HiT-MDS) for cDNA-array expression data. Lecture notes in computer science. 3696, 625-633. https://doi.org/10.1007/11550822_97


Last updated on 2025-06-06 at 11:33