Conference paper

Unsupervised feature selection for biomarker identification in chromatography and gene expression data


Authors listStrickert, Marc; Sreenivasulu, Nese; Peterek, Silke; Weschke, Winfriede; Mock, Hans-Peter; Seiffert, Udo

Publication year2006

Pages274-285

JournalLecture notes in computer science

Volume number4087

ISSN0302-9743

ISBN3-540-37951-7

eISSN1611-3349

DOI Linkhttps://doi.org/10.1007/11829898_25

Conference2nd IAPR Workshop on Artificial Neural Networks in Pattern Recognition

PublisherSpringer


Abstract
A novel approach to feature selection from unlabeled vector data is presented. It is based on the reconstruction of original data relationships in an auxiliary space with either weighted or omitted features. Feature weighting, on one hand; is related to the return forces of factors in a parametric data similarity measure as response to disturbance of their optimum values. Feature omission, on the other hand, inducing measurable loss of reconstruction quality, is realized in an iterative greedy way. The proposed framework allows to apply custom data similarity measures. Here, adaptive Euclidean distance and adaptive Pearson correlation are considered, the former serving as standard reference, the latter being, usefully for intensity data. Results of the different strategies are given for chromatography and gene expression data.



Authors/Editors




Citation Styles

Harvard Citation styleStrickert, M., Sreenivasulu, N., Peterek, S., Weschke, W., Mock, H. and Seiffert, U. (2006) Unsupervised feature selection for biomarker identification in chromatography and gene expression data, Lecture notes in computer science, 4087, pp. 274-285. https://doi.org/10.1007/11829898_25

APA Citation styleStrickert, M., Sreenivasulu, N., Peterek, S., Weschke, W., Mock, H., & Seiffert, U. (2006). Unsupervised feature selection for biomarker identification in chromatography and gene expression data. Lecture notes in computer science. 4087, 274-285. https://doi.org/10.1007/11829898_25


Last updated on 2025-06-06 at 12:33