Journal article

Publication year: 1997

Pages: R442-R445

Journal: American Journal of Physiology - Regulatory, Integrative and Comparative Physiology

Volume number: 273

Issue number: 1

ISSN: 0363-6119

eISSN: 1522-1490

DOI Link: https://doi.org/10.1152/ajpregu.1997.273.1.R442

Publisher: American Physiological Society

Abstract: 
Because dissection of the common hepatic vagus branch attenuated the feeding response to intraperitoneal injection of mercaptoacetate (MA), an inhibitor of fatty acid oxidation, in rats fed a fat-enriched diet (15% fat), the effect of MA on the discharge rate in afferents of the common hepatic vagus branch was investigated. Intraportal infusion of the Na salt of MA (200, 400, and 800 mu mol/kg) in rats adapted to the 18% fat diet dose dependently increased the discharge rate in afferents of the common hepatic vagus branch, whereas NaCl and the Na salt of the structurally related compound 8-mercaptopropionate had no effect. The lowest dose of MA yielding a significant increase in the discharge rate was 400 mu mol/kg. This agrees with the dose dependence of the feeding response to MA. These findings are consistent with the notion that hepatic fatty acid oxidation controls food intake by modulating the discharge rate of vagal afferents.

Harvard Citation style: Lutz, T., Diener, M. and Scharrer, E. (1997) Intraportal mercaptoacetate infusion increases afferent activity in the common hepatic vagus branch of the rat, American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 273(1), pp. R442-R445. https://doi.org/10.1152/ajpregu.1997.273.1.R442

APA Citation style: Lutz, T., Diener, M., & Scharrer, E. (1997). Intraportal mercaptoacetate infusion increases afferent activity in the common hepatic vagus branch of the rat. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology. 273(1), R442-R445. https://doi.org/10.1152/ajpregu.1997.273.1.R442