Journalartikel

Jahr der Veröffentlichung: 1996

Seiten: 33-40

Zeitschrift: Acta physiologica Scandinavica

Bandnummer: 157

Heftnummer: 1

ISSN: 0001-6772

DOI Link: https://doi.org/10.1046/j.1365-201X.1996.470184000.x

Verlag: Blackwell

Abstract: 
The short-chain fatty acids acetate, propionate and butyrate induced a concentration-dependent increase of short-circuit current (I-sc) in the rat distal small intestine in vitro. They were ineffective in the proximal small intestine. The increase of I-sc in the distal small intestine was dependent on the presence of Cl- and HCO3- ions. it was blocked by the inhibitor of the Na+-K+-Cl--cotransporter, bumetanide, and by the Cl- channel blocker. 5-nitro-2-(3-phenylpropylamino)-benzoate, indicating that short-chain fatty acids evoke an anion secretion. The secretion induced by propionate was blocked by the neurotoxin, tetrodotoxin, and inhibited by the muscarinic antagonists. atropine. In contrast, indomethacin, a cyclooxygenase inhibitor, or nordihydroguaiaretic acid, a lipoxygenase inhibitor, were ineffective. These results indicate that short-chain fatty acids stimulate chemosensitive neurones in the rat small intestine in a region-specific manner, which induce anion secretion by the release of mainly acetylcholine.

Harvard-Zitierstil: Diener, M., Vujicic, Z. and Scharrer, E. (1996) Neuronally mediated anion secretion induced by short-chain fatty acids in the rat distal small intestine, Acta physiologica Scandinavica, 157(1), pp. 33-40. https://doi.org/10.1046/j.1365-201X.1996.470184000.x

APA-Zitierstil: Diener, M., Vujicic, Z., & Scharrer, E. (1996). Neuronally mediated anion secretion induced by short-chain fatty acids in the rat distal small intestine. Acta physiologica Scandinavica. 157(1), 33-40. https://doi.org/10.1046/j.1365-201X.1996.470184000.x